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Target Report Card

Target Name and Classification

Target ID CHEMBL4883
Preferred Name Urokinase plasminogen activator surface receptor
Synonyms CD_antigen=CD87 | MO3 | Monocyte activation antigen Mo3 | PLAUR | U-PAR | UPAR | Urokinase plasminogen activator surface receptor | uPAR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Urokinase plasminogen activator surface receptor SINGLE PROTEIN Q03405

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000011422
Ensembl ENSG00000011422
GO Cellular Component GO:0005576 (extracellular region)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0019898 (extrinsic component of membrane)
GO:0030054 (cell junction)
GO:0031225 (anchored component of membrane)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO:0071438 (invadopodium membrane)
GO Molecular Function GO:0004872 (receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0030377 (urokinase plasminogen activator receptor activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006928 (movement of cell or subcellular component)
GO:0006935 (chemotaxis)
GO:0007165 (signal transduction)
GO:0007596 (blood coagulation)
GO:0016255 (attachment of GPI anchor to protein)
GO:0030162 (regulation of proteolysis)
GO:0038195 (urokinase plasminogen activator signaling pathway)
GO:0042730 (fibrinolysis)
GO:0043066 (negative regulation of apoptotic process)
GO:0043388 (positive regulation of DNA binding)
GO:0045742 (positive regulation of epidermal growth factor receptor signaling pathway)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
GO:2001268 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
Wikipedia Urokinase_receptor

Target Cross References - Protein

canSAR Q03405
Human Protein Atlas ENSG00000011422
IntAct Q03405
Open Targets ENSG00000011422
PharmGKB PA33383
Reactome R-HSA-162791 (Attachment of GPI anchor to uPAR.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-75205 (Dissolution of Fibrin Clot.)
UniProt A8K409 Q03405 Q12876 Q15845 Q16887 Q6IB52 Q9BWT0 Q9NYC8 Q9UD69 Q9UEA6 Q9UM92 Q9UMV0

Target Cross References - Domain

InterPro IPR016054 (LY6_UPA_recep-like.)
IPR018363 (CD59_antigen_CS.)
IPR033084 (U-PAR.)
Pfam PF00021 (UPAR_LY6)

Target Cross References - Structure

PDBe 1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI
CREDO 1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI