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Target Report Card

Target Name and Classification

Target ID CHEMBL4881
Preferred Name Aldehyde dehydrogenase X
Synonyms ALDH1B1 | ALDH5 | ALDHX | Aldehyde dehydrogenase 5 | Aldehyde dehydrogenase X, mitochondrial | Aldehyde dehydrogenase family 1 member B1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldehyde dehydrogenase X, mitochondrial SINGLE PROTEIN P30837

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542434 Aldehyde dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137124
Ensembl ENSG00000137124
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004029 (aldehyde dehydrogenase (NAD) activity)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006068 (ethanol catabolic process)
GO:0006069 (ethanol oxidation)
GO:0008152 (metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia ALDH1B1

Target Cross References - Protein

Human Protein Atlas ENSG00000137124
IntAct P30837
Open Targets ENSG00000137124
PharmGKB PA24695
Reactome R-HSA-71384 (Ethanol oxidation.)
UniProt B2R8F0 P30837 Q8WX76 Q9BV45

Target Cross References - Domain

InterPro IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS_CYS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
IPR029510 (Ald_DH_CS_GLU.)
Pfam PF00171 (Aldedh)