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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4880
Target Type SINGLE PROTEIN
Preferred Name Triosephosphate isomerase
Synonyms TIM | TPI | TPI1 | Triose-phosphate isomerase | Triosephosphate isomerase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Triosephosphate isomerase SINGLE PROTEIN P60174

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111669
Ensembl ENSG00000111669
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004807 (triose-phosphate isomerase activity)
GO:0005515 (protein binding)
GO:0016853 (isomerase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO Biological Process GO:0006006 (glucose metabolic process)
GO:0006094 (gluconeogenesis)
GO:0006096 (glycolytic process)
GO:0006098 (pentose-phosphate shunt)
GO:0007275 (multicellular organism development)
GO:0008152 (metabolic process)
GO:0019563 (glycerol catabolic process)
GO:0019682 (glyceraldehyde-3-phosphate metabolic process)
GO:0046166 (glyceraldehyde-3-phosphate biosynthetic process)
GO:0061621 (canonical glycolysis)
Wikipedia TPI1

Target Cross References - Protein

CGD Triosephosphate isomerase deficiency
Human Protein Atlas ENSG00000111669
IntAct P60174
Open Targets ENSG00000111669
PharmGKB PA36689
Reactome R-HSA-70171 (Glycolysis.)
R-HSA-70263 (Gluconeogenesis.)
UniProt B7Z5D8 D3DUS9 P00938 P60174 Q6FHP9 Q6IS07 Q8WWD0 Q96AG5

Target Cross References - Domain

InterPro IPR000652 (Triosephosphate_isomerase.)
IPR013785 (Aldolase_TIM.)
IPR020861 (Triosephosphate_isomerase_AS.)
IPR022896 (TrioseP_Isoase_bac/euk.)
Pfam PF00121 (TIM)

Target Cross References - Structure

PDBe 1HTI 1KLG 1KLU 1WYI 2IAM 2IAN 2JK2 2VOM 4BR1 4E41 4POC 4POD 4UNK 4UNL 4ZVJ
CREDO 1HTI 1KLG 1KLU 1WYI 2IAM 2IAN 2JK2 2VOM 4BR1 4E41 4POC 4POD 4UNK 4UNL 4ZVJ
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