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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4877
Preferred Name Neuropeptide Y receptor type 4
Synonyms NPY4-R | NPY4R | Neuropeptide Y receptor type 4 | PP1 | PPYR1 | Pancreatic polypeptide receptor 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > neuropeptide y receptor

Target Components

Component Description Relationship Accession
Neuropeptide Y receptor type 4 SINGLE PROTEIN P50391

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545106 TM30339 Neuropeptide Y receptor type 4 agonist 2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204174
Ensembl ENSG00000204174
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001601 (peptide YY receptor activity)
GO:0001602 (pancreatic polypeptide receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004983 (neuropeptide Y receptor activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007586 (digestion)
GO:0007631 (feeding behavior)
GO:0008015 (blood circulation)
Wikipedia Pancreatic_polypeptide_receptor_1

Target Cross References - Protein

canSAR P50391
Human Protein Atlas ENSG00000204174
Guide to Pharmacology 307
Open Targets ENSG00000204174
PharmGKB PA33692
Pharos P50391 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P50391 Q13456 Q5ISU3 Q5T2X9 Q6FH06

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000611 (NPY_rcpt.)
IPR001933 (NPY4_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)