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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4872
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated potassium channel beta subunit Mink
Synonyms Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | Minimal potassium channel | Potassium voltage-gated channel subfamily E member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • auxiliary transport protein > slow voltage-gated potassium channel accessory protein family

Target Components

Component Description Relationship Accession
Potassium voltage-gated channel subfamily E member 1 SINGLE PROTEIN P15382

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221347 Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180509
Ensembl ENSG00000180509
GO Cellular Component GO:0005764 (lysosome)
GO:0005886 (plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030018 (Z disc)
GO:0045121 (membrane raft)
GO Molecular Function GO:0005244 (voltage-gated ion channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005251 (delayed rectifier potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005515 (protein binding)
GO:0015459 (potassium channel regulator activity)
GO:0031433 (telethonin binding)
GO:0086008 (voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)
GO:1902282 (voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)
GO Biological Process GO:0006487 (protein N-linked glycosylation)
GO:0006493 (protein O-linked glycosylation)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0007605 (sensory perception of sound)
GO:0034765 (regulation of ion transmembrane transport)
GO:0060307 (regulation of ventricular cardiac muscle cell membrane repolarization)
GO:0061337 (cardiac conduction)
GO:0071320 (cellular response to cAMP)
GO:0071435 (potassium ion export)
GO:0071805 (potassium ion transmembrane transport)
GO:0086002 (cardiac muscle cell action potential involved in contraction)
GO:0086005 (ventricular cardiac muscle cell action potential)
GO:0086009 (membrane repolarization)
GO:0086011 (membrane repolarization during action potential)
GO:0086013 (membrane repolarization during cardiac muscle cell action potential)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0090315 (negative regulation of protein targeting to membrane)
GO:0098915 (membrane repolarization during ventricular cardiac muscle cell action potential)
GO:1901379 (regulation of potassium ion transmembrane transport)
GO:1901381 (positive regulation of potassium ion transmembrane transport)
GO:1902259 (regulation of delayed rectifier potassium channel activity)
GO:1902260 (negative regulation of delayed rectifier potassium channel activity)
Wikipedia KCNE1

Target Cross References - Protein

canSAR P15382
CGD Long QT syndrome 5; Jervell and Lange-Nielsen syndrome 2
Human Protein Atlas ENSG00000180509
IntAct P15382
Open Targets ENSG00000180509
PharmGKB PA211
Pharos P15382 (Tbio)
Reactome R-HSA-5576890 (Phase 3 - rapid repolarisation.)
R-HSA-5576893 (Phase 2 - plateau phase.)
UniProt A5H1P2 P15382 Q8N709 Q91Z94

Target Cross References - Domain

InterPro IPR000369 (K_chnl_KCNE.)
IPR005424 (K_chnl_volt-dep_bsu_KCNE1.)
Pfam PF02060 (ISK_Channel)
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