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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4869
Target Type SINGLE PROTEIN
Preferred Name Prion protein
Synonyms ALTPRP | ASCR | CD_antigen=CD230 | Major prion protein | PRIP | PRNP | PRP | PrP | PrP27-30 | PrP33-35C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • surface antigen

Target Components

Component Description Relationship Accession
Major prion protein SINGLE PROTEIN P04156

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171867
Ensembl ENSG00000171867
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0019898 (extrinsic component of membrane)
GO:0031225 (anchored component of membrane)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0005521 (lamin binding)
GO:0008017 (microtubule binding)
GO:0015631 (tubulin binding)
GO:0042802 (identical protein binding)
GO:0043008 (ATP-dependent protein binding)
GO:0044325 (ion channel binding)
GO:0046872 (metal ion binding)
GO:0051087 (chaperone binding)
GO Biological Process GO:0001933 (negative regulation of protein phosphorylation)
GO:0006878 (cellular copper ion homeostasis)
GO:0006979 (response to oxidative stress)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007611 (learning or memory)
GO:0008152 (metabolic process)
GO:0032689 (negative regulation of interferon-gamma production)
GO:0032700 (negative regulation of interleukin-17 production)
GO:0032703 (negative regulation of interleukin-2 production)
GO:0032880 (regulation of protein localization)
GO:0035690 (cellular response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0046007 (negative regulation of activated T cell proliferation)
GO:0046686 (response to cadmium ion)
GO:0046688 (response to copper ion)
GO:0050860 (negative regulation of T cell receptor signaling pathway)
GO:0051260 (protein homooligomerization)
GO:0070885 (negative regulation of calcineurin-NFAT signaling cascade)
GO:0071280 (cellular response to copper ion)
GO:1901379 (regulation of potassium ion transmembrane transport)
Wikipedia PRNP

Target Cross References - Protein

canSAR P04156
CGD Spongiform encephalopathy with neuropsychiatric features; Huntington disease-like 1; Gerstmann-Straussler disease; Creutzfeldt-Jakob disease; Insomnia, fatal familial; Dementia, Lewy body
Human Protein Atlas ENSG00000171867
IntAct P04156
Open Targets ENSG00000171867
PharmGKB PA33796
Reactome R-HSA-419037 (NCAM1 interactions.)
UniProt O60489 P04156 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19

Target Cross References - Domain

InterPro IPR000817 (Prion.)
IPR022416 (Prion/Doppel_prot_b-ribbon_dom.)
IPR025860 (Prion_N_dom.)
Pfam PF00377 (Prion)
PF11587 (Prion_bPrPp)

Target Cross References - Structure

PDBe 1I4M 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O
CREDO 1I4M 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O
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