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Target Report Card

Target Name and Classification

Target ID CHEMBL4865
Preferred Name Serotransferrin
Synonyms Beta-1 metal-binding globulin | Serotransferrin | Siderophilin | TF | Transferrin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Serotransferrin SINGLE PROTEIN P02787

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000091513
Ensembl ENSG00000091513
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005905 (clathrin-coated pit)
GO:0009925 (basal plasma membrane)
GO:0009986 (cell surface)
GO:0010008 (endosome membrane)
GO:0016324 (apical plasma membrane)
GO:0030139 (endocytic vesicle)
GO:0030665 (clathrin-coated vesicle membrane)
GO:0031232 (extrinsic component of external side of plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0031982 (vesicle)
GO:0034774 (secretory granule lumen)
GO:0045178 (basal part of cell)
GO:0048471 (perinuclear region of cytoplasm)
GO:0055037 (recycling endosome)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO:1990712 (HFE-transferrin receptor complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0008198 (ferrous iron binding)
GO:0008199 (ferric iron binding)
GO:0015091 (ferric iron transmembrane transporter activity)
GO:0034986 (iron chaperone activity)
GO:0046872 (metal ion binding)
GO:1990459 (transferrin receptor binding)
GO Biological Process GO:0001895 (retina homeostasis)
GO:0002576 (platelet degranulation)
GO:0006811 (ion transport)
GO:0006826 (iron ion transport)
GO:0006879 (cellular iron ion homeostasis)
GO:0031647 (regulation of protein stability)
GO:0033572 (transferrin transport)
GO:0043687 (post-translational protein modification)
GO:0044267 (cellular protein metabolic process)
GO:0048260 (positive regulation of receptor-mediated endocytosis)
GO:0055072 (iron ion homeostasis)
GO:0061024 (membrane organization)
GO:0071281 (cellular response to iron ion)
GO:1900390 (regulation of iron ion import)
Wikipedia Transferrin

Target Cross References - Protein

CGD Atransferrinemia
Human Protein Atlas ENSG00000091513
IntAct P02787
Open Targets ENSG00000091513
PharmGKB PA36457
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
R-HSA-8957275 (Post-translational protein phosphorylation.)
R-HSA-917937 (Iron uptake and transport.)
R-HSA-917977 (Transferrin endocytosis and recycling.)
UniProt O43890 P02787 Q1HBA5 Q9NQB8 Q9UHV0

Target Cross References - Domain

InterPro IPR001156 (Transferrin-like_dom.)
IPR016357 (Transferrin.)
IPR018195 (Transferrin_Fe_BS.)
IPR030685 (Serotransferrin_mammal.)
Pfam PF00405 (Transferrin)

Target Cross References - Structure

PDBe 1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L More...
CREDO 1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L More...