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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4865
Target Type SINGLE PROTEIN
Preferred Name Serotransferrin
Synonyms Beta-1 metal-binding globulin | Serotransferrin | Siderophilin | TF | Transferrin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Serotransferrin SINGLE PROTEIN P02787

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000091513
Ensembl ENSG00000091513
GO Cellular Component GO:0005576 (extracellular region)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005905 (coated pit)
GO:0009925 (basal plasma membrane)
GO:0010008 (endosome membrane)
GO:0016324 (apical plasma membrane)
GO:0030139 (endocytic vesicle)
GO:0030141 (stored secretory granule)
GO:0048471 (perinuclear region of cytoplasm)
GO:0055037 (recycling endosome)
GO Molecular Function GO:0008199 (ferric iron binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0006879 (cellular iron ion homeostasis)
GO:0030168 (platelet activation)
GO:0033572 (transferrin transport)
GO:0055085 (transmembrane transport)
Wikipedia Transferrin

Target Cross References - Protein

CGD Atransferrinemia
Human Protein Atlas ENSG00000091513
IntAct P02787
PharmGKB PA36457
Reactome REACT_15518 (Transmembrane transport of small molecules.)
REACT_604 (Hemostasis.)
UniProt O43890 P02787 Q1HBA5 Q9NQB8 Q9UHV0

Target Cross References - Domain

InterPro IPR001156 (Peptidase_S60.)
IPR016357 (Transferrin.)
IPR018195 (Transferrin_Fe_BS.)
Pfam PF00405 (Transferrin)

Target Cross References - Structure

PDBe 1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 2HAU 2HAV 2O7U 2O84 3FGS
CREDO 1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 2HAU 2HAV 2O7U 2O84 3FGS
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