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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4865
Target Type SINGLE PROTEIN
Preferred Name Serotransferrin
Synonyms Beta-1 metal-binding globulin | Serotransferrin | Siderophilin | TF | Transferrin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Serotransferrin SINGLE PROTEIN P02787

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000091513
Ensembl ENSG00000091513
GO Cellular Component GO:0005905 (coated pit)
GO:0031982 (vesicle)
GO:0009986 (cell surface)
GO:0016324 (apical plasma membrane)
GO:0005615 (extracellular space)
GO:0005769 (early endosome)
GO:0031232 (extrinsic component of external side of plasma membrane)
GO:0070062 (extracellular exosome)
GO:0005576 (extracellular region)
GO:0048471 (perinuclear region of cytoplasm)
GO:1990712 (HFE-transferrin receptor complex)
GO:0005770 (late endosome)
GO:0009925 (basal plasma membrane)
GO:0030139 (endocytic vesicle)
GO:0034774 (secretory granule lumen)
GO:0045178 (basal part of cell)
GO:0055037 (recycling endosome)
GO:0010008 (endosome membrane)
GO:0016023 (cytoplasmic membrane-bounded vesicle)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0015091 (ferric iron transmembrane transporter activity)
GO:0008199 (ferric iron binding)
GO:0008198 (ferrous iron binding)
GO:1990459 (transferrin receptor binding)
GO Biological Process GO:0006879 (cellular iron ion homeostasis)
GO:0007596 (blood coagulation)
GO:0055085 (transmembrane transport)
GO:0030168 (platelet activation)
GO:0001895 (retina homeostasis)
GO:0002576 (platelet degranulation)
GO:0055072 (iron ion homeostasis)
GO:0048260 (positive regulation of receptor-mediated endocytosis)
GO:0071281 (cellular response to iron ion)
GO:0031647 (regulation of protein stability)
GO:0097460 (ferrous iron import into cell)
GO:0033572 (transferrin transport)
Wikipedia Transferrin

Target Cross References - Protein

CGD Atransferrinemia
Human Protein Atlas ENSG00000091513
IntAct P02787
PharmGKB PA36457
UniProt Q9UHV0 P02787 O43890 Q1HBA5 Q9NQB8

Target Cross References - Domain

InterPro IPR018195 (Transferrin_Fe_BS.)
IPR001156 (Transferrin-like_dom.)
IPR016357 (Transferrin.)
IPR030685 (Serotransferrin_mammal.)
Pfam PF00405 (Transferrin)

Target Cross References - Structure

PDBe 1N7X 1N84 2HAU 2HAV 3V89 1B3E 1BP5 1BTJ 1FQF 1OQG 1OQH 3S9M 3S9N 1A8E 4X1D 1A8F 1D4N 1DTG 1JQF 3QYT 1D3K 1N7W 1RYO 2O7U More...
CREDO 1N7X 1N84 2HAU 2HAV 3V89 1B3E 1BP5 1BTJ 1FQF 1OQG 1OQH 3S9M 3S9N 1A8E 4X1D 1A8F 1D4N 1DTG 1JQF 3QYT 1D3K 1N7W 1RYO 2O7U More...
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