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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4861
Target Type SINGLE PROTEIN
Preferred Name Subtilisin/kexin type 4
Synonyms PC4 | PC4 | PCSK4 | Proprotein convertase 4 | Proprotein convertase subtilisin/kexin type 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession
Proprotein convertase subtilisin/kexin type 4 SINGLE PROTEIN Q6UW60

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115257
Ensembl ENSG00000115257
GO Cellular Component GO:0002080 (acrosomal membrane)
GO:0005615 (extracellular space)
GO:0016021 (integral component of membrane)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0007339 (binding of sperm to zona pellucida)
GO:0007340 (acrosome reaction)
GO:0016485 (protein processing)
GO:0048240 (sperm capacitation)
Wikipedia PCSK4

Target Cross References - Protein

Human Protein Atlas ENSG00000115257
PharmGKB PA33092
UniProt Q6UW60 Q8IY88 Q9UF79

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53.)
IPR000209 (Peptidase_S8/S53_dom.)
IPR002884 (PrprotnconvertsP.)
IPR006212 (Furin_repeat.)
IPR008979 (Galactose-bd-like.)
IPR009020 (Prot_inh_propept.)
IPR009030 (Growth_fac_rcpt.)
IPR009030 (Growth_fac_rcpt_N_dom.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023827 (Peptidase_S8_Asp-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)
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