ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4861
Preferred Name Subtilisin/kexin type 4
Synonyms PC4 | PCSK4 | Proprotein convertase 4 | Proprotein convertase subtilisin/kexin type 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession
Proprotein convertase subtilisin/kexin type 4 SINGLE PROTEIN Q6UW60

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115257
Ensembl ENSG00000115257
GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0002080 (acrosomal membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0007339 (binding of sperm to zona pellucida)
GO:0007340 (acrosome reaction)
GO:0009566 (fertilization)
GO:0016485 (protein processing)
GO:0022414 (reproductive process)
GO:0048240 (sperm capacitation)
Wikipedia PCSK4

Target Cross References - Protein

Human Protein Atlas ENSG00000115257
IntAct Q6UW60
Guide to Pharmacology 2384
Open Targets ENSG00000115257
PharmGKB PA33092
UniProt Q6UW60 Q8IY88 Q9UF79

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53_dom.)
IPR002884 (P_dom.)
IPR006212 (Furin_repeat.)
IPR008979 (Galactose-bd-like_sf.)
IPR009030 (Growth_fac_rcpt_cys_sf.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023827 (Peptidase_S8_Asp-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
IPR032815 (S8_pro-domain.)
IPR034182 (Kexin/furin.)
IPR036852 (Peptidase_S8/S53_dom_sf.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)
PF16470 (S8_pro-domain)