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Target Report Card

Target Name and Classification

Target ID CHEMBL4860
Preferred Name Apoptosis regulator Bcl-2
Synonyms Apoptosis regulator Bcl-2 | BCL2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > bcl-2 family

Target Components

Component Description Relationship Accession
Apoptosis regulator Bcl-2 SINGLE PROTEIN P10415

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000171791
Ensembl ENSG00000171791
GO Cellular Component GO:0005741 (mitochondrial outer membrane)
GO:0005789 (endoplasmic reticulum membrane)
GO:0031965 (nuclear membrane)
GO:0046930 (pore complex)
GO Molecular Function GO:0002020 (protease binding)
GO:0015267 (channel activity)
GO:0016563 (transcription activator activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0046982 (protein heterodimerization activity)
GO:0051434 (BH3 domain binding)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0001836 (release of cytochrome c from mitochondria)
GO:0006916 (anti-apoptosis)
GO:0006959 (humoral immune response)
GO:0006974 (response to DNA damage stimulus)
GO:0007565 (female pregnancy)
GO:0008629 (induction of apoptosis by intracellular signals)
GO:0008633 (activation of pro-apoptotic gene products)
GO:0009636 (response to toxin)
GO:0010039 (response to iron ion)
GO:0022898 (regulation of transmembrane transporter activity)
GO:0030307 (positive regulation of cell growth)
GO:0030890 (positive regulation of B cell proliferation)
GO:0032848 (negative regulation of cellular pH reduction)
GO:0034097 (response to cytokine stimulus)
GO:0035094 (response to nicotine)
GO:0042100 (B cell proliferation)
GO:0042493 (response to drug)
GO:0043496 (regulation of protein homodimerization activity)
GO:0043497 (regulation of protein heterodimerization activity)
GO:0043524 (negative regulation of neuron apoptosis)
GO:0046902 (regulation of mitochondrial membrane permeability)
GO:0050853 (B cell receptor signaling pathway)
GO:0051402 (neuron apoptosis)
GO:0051607 (defense response to virus)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0051902 (negative regulation of mitochondrial depolarization)
GO:0070059 (apoptosis in response to endoplasmic reticulum stress)
Wikipedia Bcl-2

Target Cross References - Protein

canSAR P10415
Human Protein Atlas ENSG00000171791
IntAct P10415
PharmGKB PA25302
Reactome REACT_578 (Apoptosis.)
TIMBAL Bcl-XL%20and%20Bcl-2
UniProt P10415 P10416 Q13842 Q16197

Target Cross References - Domain

InterPro IPR000712 (Bcl2_BH.)
IPR002475 (Bcl2-like_apoptosis.)
IPR003093 (Bcl2_BH4.)
IPR004725 (Bcl2_reg.)
IPR013278 (Apop_reg_Bcl2.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020728 (Bcl2_BH3_motif_CS.)
IPR020731 (Bcl2_BH4_motif_CS.)
Pfam PF00452 (Bcl-2)
PF02180 (BH4)

Target Cross References - Structure

PDBe 2W3L 2XA0