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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4853
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase 4
Synonyms KIAA0213 | MAP three kinase 1 | MAP3K4 | MAPK/ERK kinase kinase 4 | MAPKKK4 | MEK kinase 4 | MEKK 4 | MEKK4 | MTK1 | Mitogen-activated protein kinase kinase kinase 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 4 SINGLE PROTEIN Q9Y6R4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000085511
Ensembl ENSG00000085511
GO Cellular Component GO:0005737 (cytoplasm)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0001890 (placenta development)
GO:0006468 (protein phosphorylation)
GO:0010225 (response to UV-C)
GO:0010468 (regulation of gene expression)
GO:0016310 (phosphorylation)
GO:0019100 (male germ-line sex determination)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0035556 (intracellular signal transduction)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0051973 (positive regulation of telomerase activity)
GO:0060718 (chorionic trophoblast cell differentiation)
GO:1900745 (positive regulation of p38MAPK cascade)
GO:1904355 (positive regulation of telomere capping)
Wikipedia MAP3K4

Target Cross References - Protein

Human Protein Atlas ENSG00000085511
IntAct Q9Y6R4
Guide to Pharmacology 2079
Open Targets ENSG00000085511
PharmGKB PA30600
Pharos Q9Y6R4 (Tbio)
UniProt A6H8W0 B7ZLD3 B9EG75 Q5VTT8 Q5VTT9 Q92612 Q9H408 Q9Y6R4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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