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Target Report Card

Target Name and Classification

Target ID CHEMBL4853
Preferred Name Mitogen-activated protein kinase kinase kinase 4
Synonyms KIAA0213 | MAP three kinase 1 | MAP3K4 | MAPK/ERK kinase kinase 4 | MAPKKK4 | MEK kinase 4 | MEKK 4 | MEKK4 | MTK1 | Mitogen-activated protein kinase kinase kinase 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 4 SINGLE PROTEIN Q9Y6R4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000085511
Ensembl ENSG00000085511
GO Cellular Component GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0007254 (JNK cascade)
GO:0043507 (positive regulation of JUN kinase activity)
Wikipedia MAP3K4

Target Cross References - Protein

Human Protein Atlas ENSG00000085511
IntAct Q9Y6R4
Guide to Pharmacology 2079 (mitogen-activated protein kinase kinase kinase 4)
PharmGKB PA30600
UniProt A6H8W0 B7ZLD3 B9EG75 Q5VTT8 Q5VTT9 Q92612 Q9H408 Q9Y6R4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)