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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4852
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase kinase 5
Synonyms KHS | Kinase homologous to SPS1/STE20 | MAP4K5 | MAPK/ERK kinase kinase kinase 5 | MEK kinase kinase 5 | MEKKK 5 | Mitogen-activated protein kinase kinase kinase kinase 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase khs subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase kinase 5 SINGLE PROTEIN Q9Y4K4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008349 (MAP kinase kinase kinase kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000185 (activation of MAPKKK activity)
GO:0006468 (protein phosphorylation)
GO:0007257 (activation of JUN kinase activity)
GO:0016310 (phosphorylation)
GO:0035556 (intracellular signal transduction)
Wikipedia MAP4K5

Target Cross References - Protein

canSAR Q9Y4K4
IntAct Q9Y4K4
Guide to Pharmacology 2089
Open Targets
PharmGKB PA30613
Pharos Q9Y4K4 (Tchem)
UniProt Q8IYF6 Q9Y4K4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001180 (CNH_dom.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR021160 (MAPKKKK.)
Pfam PF00069 (Pkinase)
PF00780 (CNH)
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