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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4852
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase kinase 5
Synonyms KHS | Kinase homologous to SPS1/STE20 | MAP4K5 | MAPK/ERK kinase kinase kinase 5 | MEK kinase kinase 5 | MEKKK 5 | Mitogen-activated protein kinase kinase kinase kinase 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase khs subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase kinase 5 SINGLE PROTEIN Q9Y4K4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000012983
Ensembl ENSG00000012983
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005083 (small GTPase regulator activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0007257 (activation of JUN kinase activity)
Wikipedia MAP4K5

Target Cross References - Protein

canSAR Q9Y4K4
Human Protein Atlas ENSG00000012983
IntAct Q9Y4K4
Guide to Pharmacology 2089 (mitogen-activated protein kinase kinase kinase kinase 5)
PharmGKB PA30613
UniProt Q8IYF6 Q9Y4K4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001180 (Citron.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR021160 (MAPKKKK.)
Pfam PF00069 (Pkinase)
PF00780 (CNH)
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