ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4850
Target Type SINGLE PROTEIN
Preferred Name Receptor-type tyrosine-protein phosphatase epsilon
Synonyms PTPRE | Protein-tyrosine phosphatase epsilon | R-PTP-epsilon | Receptor-type tyrosine-protein phosphatase epsilon
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase > receptor tyrosine-protein phosphatase

Target Components

Component Description Relationship Accession
Receptor-type tyrosine-protein phosphatase epsilon SINGLE PROTEIN P23469

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132334
Ensembl ENSG00000132334
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016021 (integral component of membrane)
GO:0016021 (integral to membrane)
GO:0045111 (intermediate filament cytoskeleton)
GO Molecular Function GO:0005001 (transmembrane receptor protein tyrosine phosphatase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006470 (protein dephosphorylation)
GO:0007185 (transmembrane receptor protein tyrosine phosphatase signaling pathway)
GO:0033003 (regulation of mast cell activation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
Wikipedia PTPRE

Target Cross References - Protein

canSAR P23469
Human Protein Atlas ENSG00000132334
IntAct P23469
PharmGKB PA34014
UniProt P23469 Q13345 Q5VWH3 Q96KQ6

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000242 (Tyr_Pase_rcpt/non-rcpt.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR000387 (Tyr/Dual-specificity_Pase.)
IPR016130 (Tyr_Pase_AS.)
IPR016336 (Tyr_Pase_rcpt_a/e-type.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 2JJD
CREDO 2JJD
spacer
spacer