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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL4848
Target Type SINGLE PROTEIN
Preferred Name Eukaryotic translation initation factor
Synonyms EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initiation factor 4E | eIF-4E | eIF-4F 25 kDa subunit | eIF4E | mRNA cap-binding protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other nuclear protein

Target Components

Component Description Relationship Accession
Eukaryotic translation initiation factor 4E SINGLE PROTEIN P06730

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151247
Ensembl ENSG00000151247
GO Cellular Component GO:0005829 (cytosol)
GO:0016281 (eukaryotic translation initiation factor 4F complex)
GO:0010494 (cytoplasmic stress granule)
GO:0033391 (chromatoid body)
GO:0070062 (extracellular exosome)
GO:0048471 (perinuclear region of cytoplasm)
GO:0005737 (cytoplasm)
GO:0005845 (mRNA cap binding complex)
GO:0016442 (RISC complex)
GO:0000932 (cytoplasmic mRNA processing body)
GO Molecular Function GO:0003743 (translation initiation factor activity)
GO:0031370 (eukaryotic initiation factor 4G binding)
GO:0070491 (repressing transcription factor binding)
GO:0019899 (enzyme binding)
GO:0000339 (RNA cap binding)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0006412 (translation)
GO:0017148 (negative regulation of translation)
GO:0006413 (translational initiation)
GO:0016032 (viral process)
GO:0000289 (nuclear-transcribed mRNA poly(A) tail shortening)
GO:0008286 (insulin receptor signaling pathway)
GO:0045665 (negative regulation of neuron differentiation)
GO:0000288 (nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)
GO:0006406 (mRNA export from nucleus)
GO:0010467 (gene expression)
GO:0019827 (stem cell population maintenance)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0001662 (behavioral fear response)
GO:0044267 (cellular protein metabolic process)
GO:0006417 (regulation of translation)
GO:0019221 (cytokine-mediated signaling pathway)
Wikipedia EIF4E

Target Cross References - Protein

canSAR P06730
Human Protein Atlas ENSG00000151247
IntAct P06730
PharmGKB PA27714
UniProt Q96E95 P06730

Target Cross References - Domain

InterPro IPR019770 (TIF_eIF_4E_CS.)
IPR023398 (TIF_eIF4e-like.)
IPR001040 (TIF_eIF_4E.)
Pfam PF01652 (IF4E)

Target Cross References - Structure

PDBe 1IPB 2V8X 3TF2 4DT6 4TPW 4TQB 2V8W 4TQC 2W97 2V8Y 4BEA 1IPC 1WKW 3AM7 4AZA 4UED 3U7X 4DUM 5ABI
CREDO 1IPB 2V8X 3TF2 4DT6 4TPW 4TQB 2V8W 4TQC 2W97 2V8Y 4BEA 1IPC 1WKW 3AM7 4AZA 4UED 3U7X 4DUM 5ABI
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