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Target Report Card

Target Name and Classification

Target ID CHEMBL4848
Target Type SINGLE PROTEIN
Preferred Name Eukaryotic translation initation factor
Synonyms EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initiation factor 4E | eIF-4E | eIF-4F 25 kDa subunit | eIF4E | mRNA cap-binding protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other nuclear protein

Target Components

Component Description Relationship Accession
Eukaryotic translation initiation factor 4E SINGLE PROTEIN P06730

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151247
Ensembl ENSG00000151247
GO Cellular Component GO:0000932 (cytoplasmic mRNA processing body)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005845 (mRNA cap binding complex)
GO:0010494 (cytoplasmic stress granule)
GO:0016281 (eukaryotic translation initiation factor 4F complex)
GO:0016442 (RISC complex)
GO:0033391 (chromatoid body)
GO:0043234 (protein complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000339 (RNA cap binding)
GO:0003723 (RNA binding)
GO:0003743 (translation initiation factor activity)
GO:0005515 (protein binding)
GO:0019899 (enzyme binding)
GO:0031370 (eukaryotic initiation factor 4G binding)
GO:0044822 (poly(A) RNA binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000289 (nuclear-transcribed mRNA poly(A) tail shortening)
GO:0001662 (behavioral fear response)
GO:0006405 (RNA export from nucleus)
GO:0006406 (mRNA export from nucleus)
GO:0006412 (translation)
GO:0006413 (translational initiation)
GO:0006417 (regulation of translation)
GO:0016032 (viral process)
GO:0017148 (negative regulation of translation)
GO:0019827 (stem cell population maintenance)
GO:0030324 (lung development)
GO:0045665 (negative regulation of neuron differentiation)
GO:0045931 (positive regulation of mitotic cell cycle)
Wikipedia EIF4E

Target Cross References - Protein

canSAR P06730
Human Protein Atlas ENSG00000151247
IntAct P06730
Open Targets ENSG00000151247
PharmGKB PA27714
Reactome R-HSA-1169408 (ISG15 antiviral mechanism.)
R-HSA-156827 (L13a-mediated translational silencing of Ceruloplasmin expression.)
R-HSA-159227 (Transport of the SLBP independent Mature mRNA.)
R-HSA-159230 (Transport of the SLBP Dependant Mature mRNA.)
R-HSA-159231 (Transport of Mature mRNA Derived from an Intronless Transcript.)
R-HSA-166208 (mTORC1-mediated signalling.)
R-HSA-429947 (Deadenylation of mRNA.)
R-HSA-72649 (Translation initiation complex formation.)
R-HSA-72662 (Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.)
R-HSA-72702 (Ribosomal scanning and start codon recognition.)
R-HSA-72706 (GTP hydrolysis and joining of the 60S ribosomal subunit.)
UniProt B7Z6V1 D6RCQ6 P06730 Q96E95

Target Cross References - Domain

InterPro IPR001040 (TIF_eIF_4E.)
IPR019770 (TIF_eIF_4E_CS.)
IPR023398 (TIF_eIF4e-like.)
Pfam PF01652 (IF4E)

Target Cross References - Structure

PDBe 1IPB 1IPC 1WKW 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46
CREDO 1IPB 1IPC 1WKW 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46
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