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Target Report Card

Target Name and Classification

Target ID CHEMBL4846
Target Type SINGLE PROTEIN
Preferred Name Nck adaptor protein 1
Synonyms Cytoplasmic protein NCK1 | NCK adaptor protein 1 | NCK | NCK1 | Nck-1 | SH2/SH3 adaptor protein NCK-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Cytoplasmic protein NCK1 SINGLE PROTEIN P16333

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000158092
Ensembl ENSG00000158092
GO Cellular Component GO:0000164 (protein phosphatase type 1 complex)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005802 (trans-Golgi network)
GO:0005829 (cytosol)
GO:0005840 (ribosome)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005913 (cell-cell adherens junction)
GO:0012506 (vesicle membrane)
GO Molecular Function GO:0004860 (protein kinase inhibitor activity)
GO:0005070 (SH3/SH2 adaptor activity)
GO:0005086 (ARF guanyl-nucleotide exchange factor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008093 (cytoskeletal adaptor activity)
GO:0019904 (protein domain specific binding)
GO:0030159 (receptor signaling complex scaffold activity)
GO:0030674 (protein binding, bridging)
GO:0030971 (receptor tyrosine kinase binding)
GO:0071074 (eukaryotic initiation factor eIF2 binding)
GO:0098641 (cadherin binding involved in cell-cell adhesion)
GO Biological Process GO:0006417 (regulation of translation)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006930 (substrate-dependent cell migration, cell extension)
GO:0007015 (actin filament organization)
GO:0007172 (signal complex assembly)
GO:0016192 (vesicle-mediated transport)
GO:0016477 (cell migration)
GO:0030032 (lamellipodium assembly)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0033137 (negative regulation of peptidyl-serine phosphorylation)
GO:0036493 (positive regulation of translation in response to endoplasmic reticulum stress)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042110 (T cell activation)
GO:0043547 (positive regulation of GTPase activity)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0050852 (T cell receptor signaling pathway)
GO:0051707 (response to other organism)
GO:0060548 (negative regulation of cell death)
GO:0070262 (peptidyl-serine dephosphorylation)
GO:1902237 (positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)
GO:1903676 (positive regulation of cap-dependent translational initiation)
GO:1903679 (positive regulation of cap-independent translational initiation)
GO:1903898 (negative regulation of PERK-mediated unfolded protein response)
GO:1903912 (negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)
GO:1990441 (negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)
Wikipedia NCK1

Target Cross References - Protein

canSAR P16333
Human Protein Atlas ENSG00000158092
IntAct P16333
Open Targets ENSG00000158092
PharmGKB PA31466
Reactome R-HSA-186763 (Downstream signal transduction.)
R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-373753 (Nephrin interactions.)
R-HSA-418885 (DCC mediated attractive signaling.)
R-HSA-428540 (Activation of Rac.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-5663213 (RHO GTPases Activate WASPs and WAVEs.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt B7Z751 D3DNE3 P16333

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001452 (SH3_domain.)
IPR017304 (NCK.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF14604 (SH3_9)

Target Cross References - Structure

PDBe 2CI8 2CI9
CREDO 2CI8 2CI9
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