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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4846
Target Type SINGLE PROTEIN
Preferred Name Nck adaptor protein 1
Synonyms Cytoplasmic protein NCK1 | NCK | NCK adaptor protein 1 | NCK1 | Nck-1 | SH2/SH3 adaptor protein NCK-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Cytoplasmic protein NCK1 SINGLE PROTEIN P16333

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000158092
Ensembl ENSG00000158092
GO Cellular Component GO:0005634 (nucleus)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO Molecular Function GO:0005102 (receptor binding)
GO:0008093 (cytoskeletal adaptor activity)
GO:0030159 (receptor signaling complex scaffold activity)
GO Biological Process GO:0006417 (regulation of translation)
GO:0007172 (signal complex assembly)
GO:0007411 (axon guidance)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042110 (T cell activation)
GO:0050852 (T cell receptor signaling pathway)
Wikipedia NCK1

Target Cross References - Protein

canSAR P16333
Human Protein Atlas ENSG00000158092
IntAct P16333
PharmGKB PA31466
Reactome REACT_16888 (Signaling by PDGF.)
REACT_18266 (Axon guidance.)
REACT_23853 (Interactions of the immunoglobulin superfamily (IgSF) member proteins.)
REACT_6900 (Signaling in Immune system.)
UniProt D3DNE3 P16333

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001452 (SH3_domain.)
IPR017304 (Cytoplasmic_NCK.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)

Target Cross References - Structure

PDBe 2CI8 2CI9
CREDO 2CI8 2CI9
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