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Target Report Card

Target Name and Classification

Target ID CHEMBL4835
Preferred Name L-lactate dehydrogenase A chain
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
L-lactate dehydrogenase A chain SINGLE PROTEIN P00338

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134333
Ensembl ENSG00000134333
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0035686 (sperm fibrous sheath)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO:0005634 (nucleus)
GO Molecular Function GO:0051287 (NAD binding)
GO:0004459 (L-lactate dehydrogenase activity)
GO Biological Process GO:0009749 (response to glucose)
GO:0042493 (response to drug)
GO:0044281 (small molecule metabolic process)
GO:0001666 (response to hypoxia)
GO:0019674 (NAD metabolic process)
GO:0006090 (pyruvate metabolic process)
GO:0007584 (response to nutrient)
GO:0031668 (cellular response to extracellular stimulus)
GO:0043627 (response to estrogen)
GO:0006096 (glycolytic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0006089 (lactate metabolic process)
GO:0044237 (cellular metabolic process)
GO:0048569 (post-embryonic organ development)
GO:0051591 (response to cAMP)
GO:0021762 (substantia nigra development)
GO:0042542 (response to hydrogen peroxide)
Wikipedia LDHA

Target Cross References - Protein

canSAR P00338
CGD Glycogen storage disease XI
Human Protein Atlas ENSG00000134333
IntAct P00338
PharmGKB PA30319
UniProt D3DQY3 P00338 Q53G53 Q6ZNV1 Q9UDE8 Q9UDE9 Q6IBM7

Target Cross References - Domain

InterPro IPR015955 (Lactate_DH/Glyco_Ohase_4_C.)
IPR011304 (L-lactate_DH.)
IPR001236 (Lactate/malate_DH_N.)
IPR001557 (L-lactate/malate_DH.)
IPR016040 (NAD(P)-bd_dom.)
IPR018177 (L-lactate_DH_AS.)
IPR022383 (Lactate/malate_DH_C.)
Pfam PF02866 (Ldh_1_C)
PF00056 (Ldh_1_N)

Target Cross References - Structure

PDBe 4AJP 4R68 1I10 4OKN 4QSM 4JNK 4L4R 4QO8 4RLS 4L4S 4M49 4R69 4QO7 4OJN 4QT0
CREDO 4AJP 4R68 1I10 4OKN 4QSM 4JNK 4L4R 4QO8 4RLS 4L4S 4M49 4R69 4QO7 4OJN 4QT0