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Target Report Card

Target Name and Classification

Target ID CHEMBL4835
Preferred Name L-lactate dehydrogenase A chain
Synonyms Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | Renal carcinoma antigen NY-REN-59
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
L-lactate dehydrogenase A chain SINGLE PROTEIN P00338

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134333
Ensembl ENSG00000134333
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004457 (lactate dehydrogenase activity)
GO:0004459 (L-lactate dehydrogenase activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0019900 (kinase binding)
GO:0042802 (identical protein binding)
GO:0051287 (NAD binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0005975 (carbohydrate metabolic process)
GO:0006089 (lactate metabolic process)
GO:0006090 (pyruvate metabolic process)
GO:0006096 (glycolytic process)
GO:0007584 (response to nutrient)
GO:0009749 (response to glucose)
GO:0014070 (response to organic cyclic compound)
GO:0019674 (NAD metabolic process)
GO:0019752 (carboxylic acid metabolic process)
GO:0021762 (substantia nigra development)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043065 (positive regulation of apoptotic process)
GO:0043627 (response to estrogen)
GO:0048569 (post-embryonic organ development)
GO:0051591 (response to cAMP)
GO:0055114 (oxidation-reduction process)
Wikipedia LDHA

Target Cross References - Protein

canSAR P00338
CGD Glycogen storage disease XI
Human Protein Atlas ENSG00000134333
IntAct P00338
Open Targets ENSG00000134333
PharmGKB PA30319
Reactome R-HSA-70268 (Pyruvate metabolism.)
UniProt B4DKQ2 B7Z5E3 D3DQY3 F8W819 P00338 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9

Target Cross References - Domain

InterPro IPR001236 (Lactate/malate_DH_N.)
IPR001557 (L-lactate/malate_DH.)
IPR011304 (L-lactate_DH.)
IPR015955 (Lactate_DH/Glyco_Ohase_4_C.)
IPR016040 (NAD(P)-bd_dom.)
IPR018177 (L-lactate_DH_AS.)
IPR022383 (Lactate/malate_DH_C.)
Pfam PF00056 (Ldh_1_N)
PF02866 (Ldh_1_C)

Target Cross References - Structure

PDBe 1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY
CREDO 1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY