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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4833
Preferred Name Folate transporter 1
Synonyms FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier 1 | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | SLC19A1 | Solute carrier family 19 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc19 family of vitamin transporters

Target Components

Component Description Relationship Accession
Folate transporter 1 SINGLE PROTEIN P41440

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173638
Ensembl ENSG00000173638
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0031526 (brush border membrane)
GO Molecular Function GO:0005542 (folic acid binding)
GO:0008517 (folic acid transporter activity)
GO:0008518 (reduced folate carrier activity)
GO:0015350 (methotrexate transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0007565 (female pregnancy)
GO:0015884 (folic acid transport)
GO:0046655 (folic acid metabolic process)
GO:0051958 (methotrexate transport)
GO:0055085 (transmembrane transport)
GO:0098838 (reduced folate transmembrane transport)
Wikipedia SLC19A1

Target Cross References - Protein

canSAR P41440
Human Protein Atlas ENSG00000173638
IntAct P41440
Guide to Pharmacology 1014
Open Targets ENSG00000173638
PharmGKB PA327
Reactome R-HSA-196757 (Metabolism of folate and pterines.)
UniProt B2R7U8 B7Z8C3 E9PFY4 O00553 O60227 P41440 Q13026 Q9BTX8

Target Cross References - Domain

InterPro IPR002666 (Folate_carrier.)
IPR020846 (MFS_dom.)
IPR028339 (RFC.)
Pfam PF01770 (Folate_carrier)