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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4833
Preferred Name Folate transporter 1
Synonyms FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier 1 | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | SLC19A1 | Solute carrier family 19 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc19 family of vitamin transporters

Target Components

Component Description Relationship Accession
Folate transporter 1 SINGLE PROTEIN P41440

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173638
Ensembl ENSG00000173638
GO Cellular Component GO:0005624 (membrane fraction)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0005542 (folic acid binding)
GO:0008517 (folic acid transporter activity)
GO:0008518 (reduced folate carrier activity)
GO:0015350 (methotrexate transporter activity)
GO Biological Process GO:0046655 (folic acid metabolic process)
Wikipedia SLC19A1

Target Cross References - Protein

canSAR P41440
Human Protein Atlas ENSG00000173638
Guide to Pharmacology 1014 (Reduced folate transporter 1)
PharmGKB PA327
Reactome REACT_11193 (Metabolism of vitamins and cofactors.)
UniProt B2R7U8 O00553 O60227 P41440 Q13026

Target Cross References - Domain

InterPro IPR002666 (Folate_carrier.)
IPR016196 (MFS_dom_general_subst_transpt.)
Pfam PF01770 (Folate_carrier)