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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4832
Target Type SINGLE PROTEIN
Preferred Name Transcription initiation factor IIA alpha and bTranscription initiation factor IIA alpha and beta chains
Synonyms GTF2A1 | General transcription factor IIA subunit 1 | TF2A1 | TFIIA p19 subunit | TFIIA p35 subunit | TFIIA-42 | TFIIAL | Transcription initiation factor IIA alpha chain | Transcription initiation factor IIA beta chain | Transcription initiation factor IIA subunit 1 | Transcription initiation factor TFIIA 42 kDa subunit
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Transcription initiation factor IIA subunit 1 SINGLE PROTEIN P52655

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165417
Ensembl ENSG00000165417
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005672 (transcription factor TFIIA complex)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003713 (transcription coactivator activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0017025 (TBP-class protein binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006368 (transcription elongation from RNA polymerase II promoter)
GO:0042795 (snRNA transcription from RNA polymerase II promoter)
Wikipedia GTF2A1

Target Cross References - Protein

canSAR P52655
Human Protein Atlas ENSG00000165417
IntAct P52655
Open Targets ENSG00000165417
PharmGKB PA29033
Reactome R-HSA-167161 (HIV Transcription Initiation.)
R-HSA-167162 (RNA Polymerase II HIV Promoter Escape.)
R-HSA-167172 (Transcription of the HIV genome.)
R-HSA-674695 (RNA Polymerase II Pre-transcription Events.)
R-HSA-6807505 (RNA polymerase II transcribes snRNA genes.)
R-HSA-73776 (RNA Polymerase II Promoter Escape.)
R-HSA-73779 (RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.)
R-HSA-75953 (RNA Polymerase II Transcription Initiation.)
R-HSA-76042 (RNA Polymerase II Transcription Initiation And Promoter Clearance.)
UniProt P52655 Q3KNQ9

Target Cross References - Domain

InterPro IPR004855 (TFIIA_asu/bsu.)
IPR009083 (TFIIA_a-hlx.)
IPR009088 (TFIIA_b-brl.)
IPR013028 (TFIIA_asu_N.)
Pfam PF03153 (TFIIA)

Target Cross References - Structure

PDBe 1NVP
CREDO 1NVP
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