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Target Report Card

Target Name and Classification

Target ID CHEMBL4816
Preferred Name Serine/threonine-protein kinase AKT3
Synonyms AKT3 | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase akt family

Target Components

Component Description Relationship Accession
RAC-gamma serine/threonine-protein kinase SINGLE PROTEIN Q9Y243

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111353 Serine/threonine-protein kinase AKT PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545003 MSC-2363318A Serine/threonine-protein kinase AKT3 inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117020 ENSG00000275199
Ensembl ENSG00000117020 ENSG00000275199
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000002 (mitochondrial genome maintenance)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032008 (positive regulation of TOR signaling)
GO:0035556 (intracellular signal transduction)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045766 (positive regulation of angiogenesis)
GO:0045793 (positive regulation of cell size)
GO:0048854 (brain morphogenesis)
GO:0048873 (homeostasis of number of cells within a tissue)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:1905564 (positive regulation of vascular endothelial cell proliferation)
GO:1905653 (positive regulation of artery morphogenesis)
GO:2000773 (negative regulation of cellular senescence)
Wikipedia AKT3

Target Cross References - Protein

canSAR Q9Y243
Human Protein Atlas ENSG00000117020 ENSG00000275199
IntAct Q9Y243
Guide to Pharmacology 2286
Open Targets ENSG00000117020 ENSG00000275199
PharmGKB PA24686
Pharos Q9Y243 (Tchem)
Reactome R-HSA-111447 (Activation of BAD and translocation to mitochondria.)
R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1358803 (Downregulation of ERBB2:ERBB3 signaling.)
R-HSA-198323 (AKT phosphorylates targets in the cytosol.)
R-HSA-198693 (AKT phosphorylates targets in the nucleus.)
R-HSA-199418 (Negative regulation of the PI3K/AKT network.)
R-HSA-211163 (AKT-mediated inactivation of FOXO1A.)
R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-6804759 (Regulation of TP53 Activity through Association with Co-factors.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-8876198 (RAB GEFs exchange GTP for GDP on RABs.)
R-HSA-8941332 (RUNX2 regulates genes involved in cell migration.)
R-HSA-8948751 (Regulation of PTEN stability and activity.)
UniProt Q0VAA6 Q5VTI1 Q5VTI2 Q96QV3 Q9UFP5 Q9Y243

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001849 (PH_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011993 (PH-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR034675 (Akt3.)
Pfam PF00069 (Pkinase)
PF00169 (PH)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 2X18