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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4812
Preferred Name Kallikrein 8
Synonyms KLK8 | Kallikrein-8 | NP | NRPN | Neuropsin | Ovasin | PRSS19 | Serine protease 19 | Serine protease TADG-14 | TADG14 | Tumor-associated differentially expressed gene 14 protein | hK8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Kallikrein-8 SINGLE PROTEIN O60259

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000129455
Ensembl ENSG00000129455
GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007613 (memory)
GO:0008219 (cell death)
GO:0009611 (response to wounding)
GO:0031642 (negative regulation of myelination)
GO:0043616 (keratinocyte proliferation)
GO:0048681 (negative regulation of axon regeneration)
GO:0048812 (neuron projection morphogenesis)
GO:0050807 (regulation of synapse organization)
Wikipedia KLK8

Target Cross References - Protein

canSAR O60259
Human Protein Atlas ENSG00000129455
Guide to Pharmacology 2378 (kallikrein-related peptidase 8)
PharmGKB PA30158
UniProt O60259 Q5V9X1 Q5V9X2 Q8IW69 Q9HCB3 Q9NR68 Q9NR69 Q9UIL9 Q9UQ47

Target Cross References - Domain

InterPro IPR001254 (Peptidase_S1_S6.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Pept_cys/ser_Trypsin-like.)
IPR018114 (Peptidase_S1/S6_AS.)
Pfam PF00089 (Trypsin)