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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4810
Target Type SINGLE PROTEIN
Preferred Name Terminal deoxynucleotidyltransferase
Synonyms DNA nucleotidylexotransferase | DNTT | TDT | Terminal addition enzyme | Terminal deoxynucleotidyltransferase | Terminal transferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA nucleotidylexotransferase SINGLE PROTEIN P04053

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000107447
Ensembl ENSG00000107447
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003887 (DNA-directed DNA polymerase activity)
GO:0003912 (DNA nucleotidylexotransferase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0034061 (DNA polymerase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006259 (DNA metabolic process)
GO:0006304 (DNA modification)
GO:0071897 (DNA biosynthetic process)
Wikipedia Terminal_deoxynucleotidyl_transferase

Target Cross References - Protein

Human Protein Atlas ENSG00000107447
IntAct P04053
Open Targets ENSG00000107447
PharmGKB PA27449
UniProt P04053 Q53FH1 Q5W103 Q96E50

Target Cross References - Domain

InterPro IPR001357 (BRCT_dom.)
IPR001726 (TdT/Mu.)
IPR002054 (DNA-dir_DNA_pol_X.)
IPR010996 (DNA_pol_b-like_N.)
IPR018944 (DNA_pol_lambd_fingers_domain.)
IPR019843 (DNA_pol-X_BS.)
IPR022312 (DNA_pol_X.)
IPR027292 (TdT.)
IPR027421 (DNA_pol_X_lyase_dom.)
IPR028207 (DNA_pol_B_palm_palm.)
IPR029398 (PolB_thumb.)
Pfam PF00533 (BRCT)
PF10391 (DNA_pol_lambd_f)
PF14716 (HHH_8)
PF14791 (DNA_pol_B_thumb)
PF14792 (DNA_pol_B_palm)
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