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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4803
Target Type SINGLE PROTEIN
Preferred Name Nitric-oxide synthase, endothelial
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Nitric oxide synthase, endothelial SINGLE PROTEIN P29474

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111350 Nitric oxide synthase (inducible and endothelial) SELECTIVITY GROUP
CHEMBL2111405 Nitric-oxide synthase (endothelial and brain) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164867
Ensembl ENSG00000164867
GO Cellular Component GO:0005856 (cytoskeleton)
GO:0000139 (Golgi membrane)
GO:0005829 (cytosol)
GO:0030666 (endocytic vesicle membrane)
GO:0005634 (nucleus)
GO:0005901 (caveola)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0050661 (NADP binding)
GO:0005506 (iron ion binding)
GO:0034617 (tetrahydrobiopterin binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0004517 (nitric-oxide synthase activity)
GO:0034618 (arginine binding)
GO:0046870 (cadmium ion binding)
GO:0010181 (FMN binding)
GO:0003785 (actin monomer binding)
GO:0003958 (NADPH-hemoprotein reductase activity)
GO:0020037 (heme binding)
GO Biological Process GO:0006809 (nitric oxide biosynthetic process)
GO:0045909 (positive regulation of vasodilation)
GO:0046209 (nitric oxide metabolic process)
GO:0001974 (blood vessel remodeling)
GO:0003100 (regulation of systemic arterial blood pressure by endothelin)
GO:0006527 (arginine catabolic process)
GO:0007596 (blood coagulation)
GO:0009408 (response to heat)
GO:0044281 (small molecule metabolic process)
GO:0090382 (phagosome maturation)
GO:0010544 (negative regulation of platelet activation)
GO:0050880 (regulation of blood vessel size)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:0001542 (ovulation from ovarian follicle)
GO:0008217 (regulation of blood pressure)
GO:0014806 (smooth muscle hyperplasia)
GO:0019430 (removal of superoxide radicals)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0045766 (positive regulation of angiogenesis)
GO:0050999 (regulation of nitric-oxide synthase activity)
GO:0051926 (negative regulation of calcium ion transport)
GO:0002028 (regulation of sodium ion transport)
GO:0007263 (nitric oxide mediated signal transduction)
GO:0008285 (negative regulation of cell proliferation)
GO:0030324 (lung development)
GO:0043542 (endothelial cell migration)
GO:0045776 (negative regulation of blood pressure)
GO:0031284 (positive regulation of guanylate cyclase activity)
GO:0034405 (response to fluid shear stress)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0001525 (angiogenesis)
GO:0001701 (in utero embryonic development)
GO:0043267 (negative regulation of potassium ion transport)
GO:0051346 (negative regulation of hydrolase activity)
GO:0003057 (regulation of the force of heart contraction by chemical signal)
GO:0007005 (mitochondrion organization)
GO:0014740 (negative regulation of muscle hyperplasia)
Wikipedia Endothelial_NOS

Target Cross References - Protein

canSAR P29474
Human Protein Atlas ENSG00000164867
IntAct P29474
Guide to Pharmacology 1249 (Endothelial NOS)
PharmGKB PA254
UniProt Q9UDC6 Q13662 Q6GSL5 P29474 Q548C1 B2RCQ1 Q14434 Q14251 A8KA63

Target Cross References - Domain

InterPro IPR017938 (Riboflavin_synthase-like_b-brl.)
IPR001094 (Flavdoxin.)
IPR001709 (Flavoprot_Pyr_Nucl_cyt_Rdtase.)
IPR004030 (NOS_N.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR029039 (Flavoprotein-like.)
IPR003097 (FAD-binding_1.)
IPR001433 (OxRdtase_FAD/NAD-bd.)
IPR012144 (NOS_euk.)
IPR023173 (NADPH_Cyt_P450_Rdtase_dom3.)
IPR008254 (Flavodoxin/NO_synth.)
Pfam PF00667 (FAD_binding_1)
PF00258 (Flavodoxin_1)
PF00175 (NAD_binding_1)
PF02898 (NO_synthase)

Target Cross References - Structure

PDBe 1M9J 1M9K 1M9Q 1M9R 1M9M 3EAH 4D1P 3NOS 4D1O 1NIW
CREDO 1M9J 1M9K 1M9Q 1M9R 1M9M 3EAH 4D1P 3NOS 4D1O 1NIW
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