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Target Report Card

Target Name and Classification

Target ID CHEMBL4803
Target Type SINGLE PROTEIN
Preferred Name Nitric-oxide synthase, endothelial
Synonyms Constitutive NOS | EC-NOS | Endothelial NOS | NOS type III | NOS3 | NOSIII | Nitric oxide synthase, endothelial | cNOS | eNOS
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Nitric oxide synthase, endothelial SINGLE PROTEIN P29474

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111350 Nitric oxide synthase (inducible and endothelial) SELECTIVITY GROUP
CHEMBL2111405 Nitric-oxide synthase (endothelial and brain) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164867
Ensembl ENSG00000164867
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0030666 (endocytic vesicle membrane)
GO Molecular Function GO:0003785 (actin monomer binding)
GO:0004517 (nitric-oxide synthase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0010181 (FMN binding)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0034617 (tetrahydrobiopterin binding)
GO:0034618 (arginine binding)
GO:0046870 (cadmium ion binding)
GO:0046872 (metal ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0050661 (NADP binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001542 (ovulation from ovarian follicle)
GO:0001701 (in utero embryonic development)
GO:0001974 (blood vessel remodeling)
GO:0002028 (regulation of sodium ion transport)
GO:0003057 (regulation of the force of heart contraction by chemical signal)
GO:0003100 (regulation of systemic arterial blood pressure by endothelin)
GO:0006527 (arginine catabolic process)
GO:0006809 (nitric oxide biosynthetic process)
GO:0007005 (mitochondrion organization)
GO:0007263 (nitric oxide mediated signal transduction)
GO:0008217 (regulation of blood pressure)
GO:0008285 (negative regulation of cell proliferation)
GO:0009408 (response to heat)
GO:0010544 (negative regulation of platelet activation)
GO:0014740 (negative regulation of muscle hyperplasia)
GO:0014806 (smooth muscle hyperplasia)
GO:0019430 (removal of superoxide radicals)
GO:0030324 (lung development)
GO:0031284 (positive regulation of guanylate cyclase activity)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0034405 (response to fluid shear stress)
GO:0043267 (negative regulation of potassium ion transport)
GO:0043542 (endothelial cell migration)
GO:0045454 (cell redox homeostasis)
GO:0045766 (positive regulation of angiogenesis)
GO:0045776 (negative regulation of blood pressure)
GO:0045909 (positive regulation of vasodilation)
GO:0050880 (regulation of blood vessel size)
GO:0050999 (regulation of nitric-oxide synthase activity)
GO:0051346 (negative regulation of hydrolase activity)
GO:0051926 (negative regulation of calcium ion transport)
GO:0055114 (oxidation-reduction process)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
Wikipedia Endothelial_NOS

Target Cross References - Protein

canSAR P29474
Human Protein Atlas ENSG00000164867
IntAct P29474
Guide to Pharmacology 1249
Open Targets ENSG00000164867
PharmGKB PA254
Reactome R-HSA-1222556 (ROS, RNS production in phagocytes.)
R-HSA-1474151 (Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.)
R-HSA-203615 (eNOS activation.)
R-HSA-203641 (NOSTRIN mediated eNOS trafficking.)
R-HSA-203754 (NOSIP mediated eNOS trafficking.)
R-HSA-392154 (Nitric oxide stimulates guanylate cyclase.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
UniProt A0S0A7 A0S0A8 A8KA63 B2RCQ1 E9PFR2 P29474 Q13662 Q14251 Q14434 Q548C1 Q6GSL5 Q9UDC6

Target Cross References - Domain

InterPro IPR001094 (Flavdoxin-like.)
IPR001433 (OxRdtase_FAD/NAD-bd.)
IPR001709 (Flavoprot_Pyr_Nucl_cyt_Rdtase.)
IPR003097 (FAD-binding_1.)
IPR004030 (NOS_N.)
IPR008254 (Flavodoxin/NO_synth.)
IPR012144 (NOS_euk.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
IPR023173 (NADPH_Cyt_P450_Rdtase_dom3.)
IPR029039 (Flavoprotein-like_dom.)
Pfam PF00175 (NAD_binding_1)
PF00258 (Flavodoxin_1)
PF00667 (FAD_binding_1)
PF02898 (NO_synthase)

Target Cross References - Structure

PDBe 1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 3EAH 3NOS 4D1O 4D1P
CREDO 1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 3EAH 3NOS 4D1O 4D1P
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