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Target Report Card

Target Name and Classification

Target ID CHEMBL4801
Target Type SINGLE PROTEIN
Preferred Name Caspase-1
Synonyms CASP-1 | CASP1 | Caspase-1 subunit p10 | Caspase-1 subunit p20 | Caspase-1 | ICE | IL-1 beta-converting enzyme | IL-1BC | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme | p45
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-1 SINGLE PROTEIN P29466

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831289 Caspase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105721 NIVOCASAN Caspase-1 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137752
Ensembl ENSG00000137752
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0072557 (IPAF inflammasome complex)
GO:0072558 (NLRP1 inflammasome complex)
GO:0072559 (NLRP3 inflammasome complex)
GO:0097169 (AIM2 inflammasome complex)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0008656 (cysteine-type endopeptidase activator activity involved in apoptotic process)
GO:0016787 (hydrolase activity)
GO:0097153 (cysteine-type endopeptidase activity involved in apoptotic process)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006508 (proteolysis)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007165 (signal transduction)
GO:0009617 (response to bacterium)
GO:0010506 (regulation of autophagy)
GO:0016485 (protein processing)
GO:0032496 (response to lipopolysaccharide)
GO:0032611 (interleukin-1 beta production)
GO:0033198 (response to ATP)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050717 (positive regulation of interleukin-1 alpha secretion)
GO:0050718 (positive regulation of interleukin-1 beta secretion)
GO:0050727 (regulation of inflammatory response)
GO:0051882 (mitochondrial depolarization)
GO:0060081 (membrane hyperpolarization)
GO:0070269 (pyroptosis)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071310 (cellular response to organic substance)
GO:0097300 (programmed necrotic cell death)
GO:1901998 (toxin transport)
Wikipedia Caspase_1

Target Cross References - Protein

canSAR P29466
Human Protein Atlas ENSG00000137752
IntAct P29466
Guide to Pharmacology 1617
Open Targets ENSG00000137752
PharmGKB PA26083
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-448706 (Interleukin-1 processing.)
R-HSA-6803207 (TP53 Regulates Transcription of Caspase Activators and Caspases.)
R-HSA-844456 (The NLRP3 inflammasome.)
R-HSA-844615 (The AIM2 inflammasome.)
R-HSA-844623 (The IPAF inflammasome.)
UniProt B5MDZ1 P29466 Q53EY6 Q6DMQ1 Q6GSS3 Q6PI75 Q9UCN3

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_p20.)
IPR001315 (CARD.)
IPR002138 (Pept_C14_p10.)
IPR011029 (DEATH-like_dom.)
IPR015917 (Pept_C14A.)
IPR016129 (Caspase_his_AS.)
IPR017350 (Pept_C14A_CASP1-typ.)
IPR029030 (Caspase-like_dom.)
IPR033139 (Caspase_cys_AS.)
Pfam PF00619 (CARD)

Target Cross References - Structure

PDBe 1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ More...
CREDO 1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ More...
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