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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4801
Target Type SINGLE PROTEIN
Preferred Name Caspase-1
Synonyms CASP-1 | CASP1 | Caspase-1 | Caspase-1 subunit p10 | Caspase-1 subunit p20 | ICE | IL-1 beta-converting enzyme | IL-1BC | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme | p45
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-1 SINGLE PROTEIN P29466

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137752
Ensembl ENSG00000137752
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008656 (caspase activator activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0007165 (signal transduction)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071310 (cellular response to organic substance)
Wikipedia Caspase_1

Target Cross References - Protein

canSAR P29466
Human Protein Atlas ENSG00000137752
IntAct P29466
Guide to Pharmacology 1617 (Caspase 1)
PharmGKB PA26083
Reactome REACT_6900 (Signaling in Immune system.)
UniProt B5MDZ1 P29466 Q53EY6 Q6DMQ1 Q6GSS3 Q6PI75 Q9UCN3

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_ICE_p20.)
IPR001315 (CARD.)
IPR002138 (Pept_C14_p10.)
IPR002398 (Pept_C14_p45.)
IPR011029 (DEATH-like.)
IPR011600 (Pept_C14_cat.)
IPR015917 (Pept_C14_p45_core.)
IPR016129 (Pept_C14_ICE_p20_AS.)
IPR017350 (Caspase_IL-1_beta.)
Pfam PF00619 (CARD)
PF00656 (Peptidase_C14)

Target Cross References - Structure

PDBe 1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ More...
CREDO 1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ More...
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