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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4794
Target Type SINGLE PROTEIN
Preferred Name Vanilloid receptor
Synonyms Capsaicin receptor | OTRPC1 | Osm-9-like TRP channel 1 | TRPV1 | Transient receptor potential cation channel subfamily V member 1 | TrpV1 | VR1 | Vanilloid receptor 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > transient receptor potential channel

Target Components

Component Description Relationship Accession
Transient receptor potential cation channel subfamily V member 1 SINGLE PROTEIN Q8NER1

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL112 ACETAMINOPHEN Vanilloid receptor opener 4 PubMed PubMed
CHEMBL294199 CAPSAICIN Vanilloid receptor opener 4 FDA
CHEMBL3707398 PAC-14028 Vanilloid receptor antagonist 3 PubMed
CHEMBL207433 SB-705498 Vanilloid receptor antagonist 2 PubMed
CHEMBL3544953 SAF312 Vanilloid receptor inhibitor 2 Other
CHEMBL3545039 AZD1386 Vanilloid receptor antagonist 2 PubMed
CHEMBL3545107 GRC-6211 Vanilloid receptor antagonist 2 PubMed PubMed
CHEMBL3545227 NGD-8243 Vanilloid receptor antagonist 2 PubMed
CHEMBL3545228 JTS-653 Vanilloid receptor antagonist 2 PubMed PubMed
CHEMBL3545229 DWP05195 Vanilloid receptor antagonist 2 Other PubMed
CHEMBL3707293 XEN-D0501 Vanilloid receptor antagonist 2 Other Other
CHEMBL3707356 SYL-1001 Vanilloid receptor antagonist 2 Other
CHEMBL229430 AMG-517 Vanilloid receptor antagonist 1 PubMed
CHEMBL398338 ABT-102 Vanilloid receptor antagonist 1 PubMed
CHEMBL2364618 MAVATREP Vanilloid receptor antagonist 1 ClinicalTrials
CHEMBL3545148 PHE377 Vanilloid receptor antagonist 1 Other PubMed
CHEMBL3707397 MR-1817 Vanilloid receptor antagonist 1
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196689
Ensembl ENSG00000196689
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0031226 (intrinsic component of plasma membrane)
GO:0032591 (dendritic spine membrane)
GO:0042995 (cell projection)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005231 (excitatory extracellular ligand-gated ion channel activity)
GO:0005262 (calcium channel activity)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0015278 (calcium-release channel activity)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007635 (chemosensory behavior)
GO:0050955 (thermoception)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0055085 (transmembrane transport)
GO:0070588 (calcium ion transmembrane transport)
GO:0071312 (cellular response to alkaloid)
GO:0071318 (cellular response to ATP)
Wikipedia TRPV1

Target Cross References - Protein

Human Protein Atlas ENSG00000196689
Guide to Pharmacology 507
Open Targets ENSG00000196689
PharmGKB PA37329
Pharos Q8NER1 (Tclin)
Reactome R-HSA-3295583 (TRP channels.)
UniProt A2RUA9 Q3LU47 Q8NER1 Q9H0G9 Q9H303 Q9H304 Q9NQ74 Q9NY22

Target Cross References - Domain

InterPro IPR002110 (Ankyrin_rpt.)
IPR004729 (TRP_channel.)
IPR005821 (Ion_trans_dom.)
IPR008347 (TRPV1-4_channel.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR024862 (TRPV.)
IPR024863 (TRPV1_channel.)
Pfam PF00520 (Ion_trans)
PF12796 (Ank_2)
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