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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4792
Target Type SINGLE PROTEIN
Preferred Name Orexin receptor 2
Synonyms HCRTR2 | Hypocretin receptor type 2 | Orexin receptor type 2 | Ox-2-R | Ox2-R | Ox2R
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > orexin receptor

Target Components

Component Description Relationship Accession
Orexin receptor type 2 SINGLE PROTEIN O43614

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3307226 Orexin receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545367 LEMBOREXANT Orexin receptor 2 antagonist 3 Other
CHEMBL1272307 SB-649868 Orexin receptor 2 antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137252
Ensembl ENSG00000137252
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0008188 (neuropeptide receptor activity)
GO:0016499 (orexin receptor activity)
GO:0017046 (peptide hormone binding)
GO:0042277 (peptide binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007631 (feeding behavior)
GO:0022410 (circadian sleep/wake cycle process)
GO:0032870 (cellular response to hormone stimulus)
GO:0045187 (regulation of circadian sleep/wake cycle, sleep)
GO:0051480 (regulation of cytosolic calcium ion concentration)
GO:1901652 (response to peptide)
Wikipedia Hypocretin_(orexin)_receptor_2

Target Cross References - Protein

canSAR O43614
Human Protein Atlas ENSG00000137252
Guide to Pharmacology 322
Open Targets ENSG00000137252
PharmGKB PA29223
Pharos O43614 (Tclin)
Reactome R-HSA-389397 (Orexin and neuropeptides FF and QRFP bind to their respective receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt O43614 Q5VTM0

Target Cross References - Domain

InterPro IPR000204 (Orexin_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR004060 (Orexin_rcpt_2.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
PF03827 (Orexin_rec2)

Target Cross References - Structure

PDBe 4S0V
CREDO 4S0V
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