ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4772
Preferred Name 1-acylglycerol-3-phosphate O-acyltransferase beta
Synonyms 1-AGP acyltransferase 2 | 1-AGPAT 2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta | 1-acylglycerol-3-phosphate O-acyltransferase 2 | AGPAT2 | LPAAT-beta | Lysophosphatidic acid acyltransferase beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
1-acyl-sn-glycerol-3-phosphate acyltransferase beta SINGLE PROTEIN O15120

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169692
Ensembl ENSG00000169692
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0003841 (1-acylglycerol-3-phosphate O-acyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO Biological Process GO:0001819 (positive regulation of cytokine production)
GO:0001961 (positive regulation of cytokine-mediated signaling pathway)
GO:0006629 (lipid metabolic process)
GO:0006644 (phospholipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0008152 (metabolic process)
GO:0008544 (epidermis development)
GO:0008654 (phospholipid biosynthetic process)
GO:0016024 (CDP-diacylglycerol biosynthetic process)
GO:0019432 (triglyceride biosynthetic process)
GO:0036276 (response to antidepressant)
Wikipedia AGPAT2

Target Cross References - Protein

canSAR O15120
CGD Lipodystrophy, congenital generalized, type 1
Human Protein Atlas ENSG00000169692
IntAct O15120
Open Targets ENSG00000169692
PharmGKB PA24622
Reactome R-HSA-1483166 (Synthesis of PA.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-75109 (Triglyceride Biosynthesis.)
UniProt O00516 O15106 O15120 Q5VUD3 Q5VUD4 Q9BSV7 Q9BWR7

Target Cross References - Domain

InterPro IPR002123 (Plipid/glycerol_acylTrfase.)
IPR004552 (AGP_acyltrans.)
Pfam PF01553 (Acyltransferase)