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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4770
Preferred Name Potassium channel, inwardly rectifying, subfamily J, member 8
Synonyms ATP-sensitive inward rectifier potassium channel 8 | Inward rectifier K(+) channel Kir6.1 | KCNJ8 | Potassium channel, inwardly rectifying subfamily J member 8 | uKATP-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > inwardly rectifying potassium channel

Target Components

Component Description Relationship Accession
ATP-sensitive inward rectifier potassium channel 8 SINGLE PROTEIN Q15842

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095152 Sulfonylurea receptors; K-ATP channels PROTEIN COMPLEX GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL181 DIAZOXIDE Potassium channel, inwardly rectifying, subfamily J, member 8 opener 4 DailyMed ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121361
Ensembl ENSG00000121361
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0008282 (ATP-sensitive potassium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030016 (myofibril)
GO:0042383 (sarcolemma)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0005242 (inward rectifier potassium channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005524 (ATP binding)
GO:0015272 (ATP-activated inward rectifier potassium channel activity)
GO:0017098 (sulfonylurea receptor binding)
GO Biological Process GO:0001822 (kidney development)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0007507 (heart development)
GO:0009268 (response to pH)
GO:0010107 (potassium ion import)
GO:0032496 (response to lipopolysaccharide)
GO:0034765 (regulation of ion transmembrane transport)
GO:0042311 (vasodilation)
GO:0043330 (response to exogenous dsRNA)
GO:0051607 (defense response to virus)
Wikipedia KCNJ8

Target Cross References - Protein

canSAR Q15842
Human Protein Atlas ENSG00000121361
Open Targets ENSG00000121361
PharmGKB PA30050
Pharos Q15842 (Tbio)
Reactome R-HSA-1296025 (ATP sensitive Potassium channels.)
UniProt O00657 Q15842

Target Cross References - Domain

InterPro IPR003278 (K_chnl_inward-rec_Kir6.1.)
IPR013518 (K_chnl_inward-rec_Kir_cyto.)
IPR014756 (Ig_E-set.)
IPR016449 (K_chnl_inward-rec_Kir.)
Pfam PF01007 (IRK)