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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4770
Target Type SINGLE PROTEIN
Preferred Name Potassium channel, inwardly rectifying, subfamily J, member 8
Synonyms ATP-sensitive inward rectifier potassium channel 8 | Inward rectifier K(+) channel Kir6.1 | KCNJ8 | Potassium channel, inwardly rectifying subfamily J member 8 | uKATP-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > inwardly rectifying potassium channel

Target Components

Component Description Relationship Accession
ATP-sensitive inward rectifier potassium channel 8 SINGLE PROTEIN Q15842

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095152 Sulfonylurea receptors; K-ATP channels PROTEIN COMPLEX GROUP

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL181 DIAZOXIDE Potassium channel, inwardly rectifying, subfamily J, member 8 opener DailyMed ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000121361
Ensembl ENSG00000121361
GO Cellular Component GO:0008076 (voltage-gated potassium channel complex)
Wikipedia KCNJ8

Target Cross References - Protein

canSAR Q15842
Human Protein Atlas ENSG00000121361
Guide to Pharmacology 441 (Kir6.1)
PharmGKB PA30050
UniProt O00657 Q15842

Target Cross References - Domain

InterPro IPR001838 (K_chnl_inward-rec_Kir-like.)
IPR003278 (K_chnl_inward-rec_Kir6.1.)
IPR013518 (K_chnl_inward-rec_Kir_cyto.)
IPR013521 (K_chnl_inward-rec_Kir_Cr2.)
IPR014756 (Ig_E-set.)
IPR016449 (K_chnl_inward-rec_Kir.)
Pfam PF01007 (IRK)
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