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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4766
Target Type SINGLE PROTEIN
Preferred Name Pyruvate dehydrogenase kinase isoform 1
Synonyms PDH kinase 1 | PDHK1 | PDK1 | Pyruvate dehydrogenase kinase isoform 1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase pdhk subfamily

Target Components

Component Description Relationship Accession
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial SINGLE PROTEIN Q15118

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096665 Pyruvate dehydrogenase kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152256
Ensembl ENSG00000152256
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005967 (mitochondrial pyruvate dehydrogenase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004740 (pyruvate dehydrogenase (acetyl-transferring) kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006468 (protein phosphorylation)
GO:0008283 (cell proliferation)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0010510 (regulation of acetyl-CoA biosynthetic process from pyruvate)
GO:0010906 (regulation of glucose metabolic process)
GO:0016310 (phosphorylation)
GO:0097411 (hypoxia-inducible factor-1alpha signaling pathway)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
Wikipedia PDK1

Target Cross References - Protein

canSAR Q15118
Human Protein Atlas ENSG00000152256
IntAct Q15118
Open Targets ENSG00000152256
PharmGKB PA33154
Pharos Q15118 (Tchem)
Reactome R-HSA-204174 (Regulation of pyruvate dehydrogenase (PDH) complex.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
UniProt B2R6T1 B7Z937 D3DPD8 E9PD65 Q15118 Q308M4

Target Cross References - Domain

InterPro IPR003594 (HATPase_C.)
IPR005467 (His_kinase_dom.)
IPR018955 (BCDHK/PDK_N.)
Pfam PF02518 (HATPase_c)
PF10436 (BCDHK_Adom3)

Target Cross References - Structure

PDBe 2Q8F 2Q8G 2Q8H
CREDO 2Q8F 2Q8G 2Q8H
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