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Target Report Card

Target Name and Classification

Target ID CHEMBL4766
Preferred Name Pyruvate dehydrogenase kinase isoform 1
Synonyms PDH kinase 1 | PDHK1 | PDK1 | Pyruvate dehydrogenase kinase isoform 1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > atypical protein kinase group > atypical protein kinase pdhk subfamily

Target Components

Component Description Relationship Accession
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial SINGLE PROTEIN Q15118

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096665 Pyruvate dehydrogenase kinase PROTEIN FAMILY
CHEMBL3885616 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152256
Ensembl ENSG00000152256
GO Cellular Component GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005967 (mitochondrial pyruvate dehydrogenase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004740 (pyruvate dehydrogenase (acetyl-transferring) kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006468 (protein phosphorylation)
GO:0008283 (cell proliferation)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0010510 (regulation of acetyl-CoA biosynthetic process from pyruvate)
GO:0010906 (regulation of glucose metabolic process)
GO:0016310 (phosphorylation)
GO:0097411 (hypoxia-inducible factor-1alpha signaling pathway)
Wikipedia PDK1

Target Cross References - Protein

canSAR Q15118
Human Protein Atlas ENSG00000152256
IntAct Q15118
Guide to Pharmacology 2915
Open Targets ENSG00000152256
PharmGKB PA33154
Pharos Q15118 (Tchem)
Reactome R-HSA-204174 (Regulation of pyruvate dehydrogenase (PDH) complex.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
UniProt B2R6T1 B7Z937 D3DPD8 E9PD65 Q15118 Q308M4

Target Cross References - Domain

InterPro IPR003594 (HATPase_C.)
IPR005467 (His_kinase_dom.)
IPR018955 (BCDHK/PDK_N.)
IPR036784 (AK/P_DHK_N_sf.)
IPR036890 (HATPase_C_sf.)
Pfam PF02518 (HATPase_c)
PF10436 (BCDHK_Adom3)

Target Cross References - Structure

PDBe 2Q8F 2Q8G 2Q8H