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Target Report Card

Target Name and Classification

Target ID CHEMBL4762
Target Type SINGLE PROTEIN
Preferred Name Low affinity neurotrophin receptor p75NTR
Synonyms CD_antigen=CD271 | Gp80-LNGFR | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | NGFR | TNFRSF16 | Tumor necrosis factor receptor superfamily member 16 | p75 ICD
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Tumor necrosis factor receptor superfamily member 16 SINGLE PROTEIN P08138

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000064300
Ensembl ENSG00000064300
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005791 (rough endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030135 (coated vesicle)
GO:0032590 (dendrite membrane)
GO:0032809 (neuronal cell body membrane)
GO:0043005 (neuron projection)
GO:0043204 (perikaryon)
GO:0045121 (membrane raft)
GO:0045334 (clathrin-coated endocytic vesicle)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004871 (signal transducer activity)
GO:0004872 (receptor activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005031 (tumor necrosis factor-activated receptor activity)
GO:0005168 (neurotrophin TRKA receptor binding)
GO:0005515 (protein binding)
GO:0017137 (Rab GTPase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0043121 (neurotrophin binding)
GO:0048406 (nerve growth factor binding)
GO:0070678 (preprotein binding)
GO Biological Process GO:0006886 (intracellular protein transport)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007411 (axon guidance)
GO:0009611 (response to wounding)
GO:0010942 (positive regulation of cell death)
GO:0010977 (negative regulation of neuron projection development)
GO:0019233 (sensory perception of pain)
GO:0030154 (cell differentiation)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0031643 (positive regulation of myelination)
GO:0032224 (positive regulation of synaptic transmission, cholinergic)
GO:0032496 (response to lipopolysaccharide)
GO:0032922 (circadian regulation of gene expression)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034599 (cellular response to oxidative stress)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0035914 (skeletal muscle cell differentiation)
GO:0042127 (regulation of cell proliferation)
GO:0042593 (glucose homeostasis)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048511 (rhythmic process)
GO:0050771 (negative regulation of axonogenesis)
GO:0050772 (positive regulation of axonogenesis)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0051902 (negative regulation of mitochondrial depolarization)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060548 (negative regulation of cell death)
GO:0097190 (apoptotic signaling pathway)
GO:1901216 (positive regulation of neuron death)
GO:2000377 (regulation of reactive oxygen species metabolic process)
GO:2001273 (regulation of glucose import in response to insulin stimulus)
Wikipedia Low-affinity_nerve_growth_factor_receptor

Target Cross References - Protein

canSAR P08138
Human Protein Atlas ENSG00000064300
IntAct P08138
Guide to Pharmacology 1888
Open Targets ENSG00000064300
PharmGKB PA31615
Reactome R-HSA-193634 (Axonal growth inhibition (RHOA activation).)
R-HSA-193648 (NRAGE signals death through JNK.)
R-HSA-193670 (p75NTR negatively regulates cell cycle via SC1.)
R-HSA-193681 (Ceramide signalling.)
R-HSA-193692 (Regulated proteolysis of p75NTR.)
R-HSA-205017 (NFG and proNGF binds to p75NTR.)
R-HSA-205025 (NADE modulates death signalling.)
R-HSA-205043 (NRIF signals cell death from the nucleus.)
R-HSA-209543 (p75NTR recruits signalling complexes.)
R-HSA-209560 (NF-kB is activated and signals survival.)
R-HSA-209563 (Axonal growth stimulation.)
UniProt B2R961 B4E096 P08138

Target Cross References - Domain

InterPro IPR000488 (Death_domain.)
IPR001368 (TNFR/NGFR_Cys_rich_reg.)
IPR011029 (DEATH-like_dom.)
IPR022325 (TNFR_16.)
IPR034046 (TNFRSF16_N.)
Pfam PF00020 (TNFR_c6)
PF00531 (Death)

Target Cross References - Structure

PDBe 3EWV
CREDO 3EWV
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