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Target Report Card

Target Name and Classification

Target ID CHEMBL4761
Target Type SINGLE PROTEIN
Preferred Name C3a anaphylatoxin chemotactic receptor
Synonyms AZ3B | C3AR | C3AR1 | C3R1 | C3a anaphylatoxin chemotactic receptor | C3a-R | HNFAG09
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > anaphylatoxin receptor family > anaphylatoxin receptor

Target Components

Component Description Relationship Accession
C3a anaphylatoxin chemotactic receptor SINGLE PROTEIN Q16581

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171860
Ensembl ENSG00000171860
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001850 (complement component C3a binding)
GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0004876 (complement component C3a receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004942 (anaphylatoxin receptor activity)
GO:0004943 (C3a anaphylatoxin receptor activity)
GO Biological Process GO:0002430 (complement receptor mediated signaling pathway)
GO:0002462 (tolerance induction to nonself antigen)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0008015 (blood circulation)
GO:0008217 (regulation of blood pressure)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010759 (positive regulation of macrophage chemotaxis)
GO:0030335 (positive regulation of cell migration)
GO:0030449 (regulation of complement activation)
GO:0045766 (positive regulation of angiogenesis)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0072126 (positive regulation of glomerular mesangial cell proliferation)
GO:0090023 (positive regulation of neutrophil chemotaxis)
GO:2000573 (positive regulation of DNA biosynthetic process)
Wikipedia C3a_receptor

Target Cross References - Protein

canSAR Q16581
Human Protein Atlas ENSG00000171860
Guide to Pharmacology 31
Open Targets ENSG00000171860
PharmGKB PA25898
Pharos Q16581 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-977606 (Regulation of Complement cascade.)
UniProt O43771 Q16581 Q92868

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000826 (Formyl_rcpt-rel.)
IPR001644 (Anaphtx_C3AR1.)
IPR002234 (Anphylx_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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