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Target Report Card

Target Name and Classification

Target ID CHEMBL4761
Preferred Name C3a anaphylatoxin chemotactic receptor
Synonyms AZ3B | C3AR | C3AR1 | C3R1 | C3a anaphylatoxin chemotactic receptor | C3a-R | HNFAG09
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > anaphylatoxin receptor family > anaphylatoxin receptor

Target Components

Component Description Relationship Accession
C3a anaphylatoxin chemotactic receptor SINGLE PROTEIN Q16581

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171860
Ensembl ENSG00000171860
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0035577 (azurophil granule membrane)
GO:0035579 (specific granule membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004875 (complement receptor activity)
GO:0004876 (complement component C3a receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO Biological Process GO:0002430 (complement receptor mediated signaling pathway)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0008015 (blood circulation)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010759 (positive regulation of macrophage chemotaxis)
GO:0030449 (regulation of complement activation)
GO:0043312 (neutrophil degranulation)
GO:0045766 (positive regulation of angiogenesis)
GO:0050900 (leukocyte migration)
GO:0060326 (cell chemotaxis)
GO:0090023 (positive regulation of neutrophil chemotaxis)
Wikipedia C3a_receptor

Target Cross References - Protein

canSAR Q16581
Human Protein Atlas ENSG00000171860
Guide to Pharmacology 31
Open Targets ENSG00000171860
PharmGKB PA25898
Pharos Q16581 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-977606 (Regulation of Complement cascade.)
UniProt O43771 Q16581 Q92868

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000826 (Formyl_rcpt-rel.)
IPR001644 (Anaphtx_C3AR1.)
IPR002234 (Anphylx_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)