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Target Report Card

Target Name and Classification

Target ID CHEMBL4742
Target Type SINGLE PROTEIN
Preferred Name Guanine nucleotide-binding protein G(o), alpha subunit 1
Synonyms GNAO1 | Guanine nucleotide-binding protein G(o) subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other membrane protein

Target Components

Component Description Relationship Accession
Guanine nucleotide-binding protein G(o) subunit alpha SINGLE PROTEIN P09471

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087258
Ensembl ENSG00000087258
GO Cellular Component GO:0005834 (heterotrimeric G-protein complex)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030425 (dendrite)
GO:0043005 (neuron projection)
GO:0043209 (myelin sheath)
GO:0043234 (protein complex)
GO:0044297 (cell body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0004871 (signal transducer activity)
GO:0005525 (GTP binding)
GO:0019001 (guanyl nucleotide binding)
GO:0031683 (G-protein beta/gamma-subunit complex binding)
GO:0031821 (G-protein coupled serotonin receptor binding)
GO:0031852 (mu-type opioid receptor binding)
GO:0032403 (protein complex binding)
GO:0032794 (GTPase activating protein binding)
GO:0046872 (metal ion binding)
GO:0051430 (corticotropin-releasing hormone receptor 1 binding)
GO Biological Process GO:0006457 (protein folding)
GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007223 (Wnt signaling pathway, calcium modulating pathway)
GO:0007568 (aging)
GO:0007626 (locomotory behavior)
GO:0008016 (regulation of heart contraction)
GO:0009987 (cellular process)
GO:0010243 (response to organonitrogen compound)
GO:0014070 (response to organic cyclic compound)
GO:0030900 (forebrain development)
GO:0031175 (neuron projection development)
GO:0034097 (response to cytokine)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043278 (response to morphine)
GO:0043547 (positive regulation of GTPase activity)
GO:0051926 (negative regulation of calcium ion transport)
Wikipedia GNAO1

Target Cross References - Protein

canSAR P09471
Human Protein Atlas ENSG00000087258
IntAct P09471
Open Targets ENSG00000087258
PharmGKB PA28771
Reactome R-HSA-112043 (PLC beta mediated events.)
R-HSA-202040 (G-protein activation.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-6814122 (Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.)
UniProt P09471 P29777 Q8TD72 Q9UMV4

Target Cross References - Domain

InterPro IPR001019 (Gprotein_alpha_su.)
IPR001408 (Gprotein_alpha_I.)
IPR011025 (GproteinA_insert.)
IPR027417 (P-loop_NTPase.)
Pfam PF00503 (G-alpha)
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