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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4736
Target Type SINGLE PROTEIN
Preferred Name DNA excision repair protein ERCC-5
Synonyms DNA excision repair protein ERCC-5 | DNA repair protein complementing XP-G cells | ERCC5 | ERCM2 | XPG | XPGC | Xeroderma pigmentosum group G-complementing protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other nuclear protein

Target Components

Component Description Relationship Accession
DNA repair protein complementing XP-G cells SINGLE PROTEIN P28715

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134899
Ensembl ENSG00000134899
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005662 (DNA replication factor A complex)
GO:0005675 (holo TFIIH complex)
GO:0016591 (DNA-directed RNA polymerase II, holoenzyme)
GO Molecular Function GO:0000405 (bubble DNA binding)
GO:0003677 (DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003697 (single-stranded DNA binding)
GO:0003824 (catalytic activity)
GO:0004518 (nuclease activity)
GO:0004519 (endonuclease activity)
GO:0004520 (endodeoxyribonuclease activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016788 (hydrolase activity, acting on ester bonds)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0006281 (DNA repair)
GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0006289 (nucleotide-excision repair)
GO:0006293 (nucleotide-excision repair, preincision complex stabilization)
GO:0006294 (nucleotide-excision repair, preincision complex assembly)
GO:0006295 (nucleotide-excision repair, DNA incision, 3'-to lesion)
GO:0006296 (nucleotide-excision repair, DNA incision, 5'-to lesion)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0009411 (response to UV)
GO:0009650 (UV protection)
GO:0010225 (response to UV-C)
GO:0033683 (nucleotide-excision repair, DNA incision)
GO:0043066 (negative regulation of apoptotic process)
Wikipedia ERCC5

Target Cross References - Protein

canSAR P28715
CGD Xeroderma pigmentosum, group G; Xeroderma pigmentosum, group G/Cockayne syndrome
Human Protein Atlas ENSG00000134899
IntAct P28715
Open Targets ENSG00000134899
PharmGKB PA27851
Reactome R-HSA-5696395 (Formation of Incision Complex in GG-NER.)
R-HSA-5696400 (Dual Incision in GG-NER.)
R-HSA-6782135 (Dual incision in TC-NER.)
UniProt A6NGT4 P28715 Q5JUS4 Q5JUS5 Q7Z2V3 Q8IZL6 Q8N1B7 Q9HD59 Q9HD60

Target Cross References - Domain

InterPro IPR001044 (XPG/Rad2_eukaryotes.)
IPR006084 (XPG/Rad2.)
IPR006085 (XPG_DNA_repair_N.)
IPR006086 (XPG-I_dom.)
IPR008918 (HhH2.)
IPR019974 (XPG_CS.)
IPR020045 (5-3_exonuclease_C.)
IPR029060 (PIN_domain-like.)
Pfam PF00752 (XPG_N)
PF00867 (XPG_I)

Target Cross References - Structure

PDBe 5EKF 5EKG
CREDO 5EKF 5EKG
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