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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4729
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2B6
Synonyms 1,4-cineole 2-exo-monooxygenase | CYP2B6 | CYPIIB6 | Cytochrome P450 2B6 | Cytochrome P450 IIB1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2b > cytochrome p450 2b6

Target Components

Component Description Relationship Accession
Cytochrome P450 2B6 SINGLE PROTEIN P20813

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197408
Ensembl ENSG00000197408
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0017144 (drug metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0042180 (cellular ketone metabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP2B6

Target Cross References - Protein

canSAR P20813
CGD Efavirenz, poor metabolism of
Human Protein Atlas ENSG00000197408
Guide to Pharmacology 1324
Open Targets ENSG00000197408
PharmGKB PA123
Reactome R-HSA-211935 (Fatty acids.)
R-HSA-211981 (Xenobiotics.)
R-HSA-211999 (CYP2E1 reactions.)
UniProt B4DWP3 P20813 Q2V565 Q9UK46

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008068 (Cyt_P450_E_grp-I_CYP2B-like.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 3IBD 3QOA 3QU8 3UA5 4I91 4RQL 4RRT 4ZV8 5UAP 5UDA 5UEC 5UFG
CREDO 3IBD 3QOA 3QU8 3UA5 4I91 4RQL 4RRT 4ZV8 5UAP 5UDA 5UEC 5UFG
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