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Target Report Card

Target Name and Classification

Target ID CHEMBL4722
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase Aurora-A
Synonyms AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AYK1 | Aurora 2 | Aurora kinase A | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora-A | hARK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase aur family

Target Components

Component Description Relationship Accession
Aurora kinase A SINGLE PROTEIN O14965

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430911 Serine/threonine-protein kinase Aurora PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL483158 ALISERTIB Serine/threonine-protein kinase Aurora-A inhibitor 3 PubMed
CHEMBL52885 ENMD-981693 Serine/threonine-protein kinase Aurora-A inhibitor 2 Other
CHEMBL495727 AT-9283 Serine/threonine-protein kinase Aurora-A inhibitor 2 PubMed PubMed
CHEMBL482968 ENMD-2076 Serine/threonine-protein kinase Aurora-A inhibitor 2 Other PubMed PubMed
CHEMBL259084 MLN-8054 Serine/threonine-protein kinase Aurora-A inhibitor 1 PubMed PubMed PubMed
CHEMBL1908397 KW-2449 Serine/threonine-protein kinase Aurora-A inhibitor 1 PubMed PubMed
CHEMBL1980391 RG-1530 Serine/threonine-protein kinase Aurora-A inhibitor 1 PubMed PubMed
CHEMBL3182444 MK-5108 Serine/threonine-protein kinase Aurora-A inhibitor 1 PubMed
CHEMBL3545078 PF-03814735 Serine/threonine-protein kinase Aurora-A inhibitor 1 PubMed PubMed
CHEMBL3545326 TAS-119 Serine/threonine-protein kinase Aurora-A inhibitor 1 DOI Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087586
Ensembl ENSG00000087586
GO Cellular Component GO:0000780 (condensed nuclear chromosome, centromeric region)
GO:0000922 (spindle pole)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005814 (centriole)
GO:0005815 (microtubule organizing center)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005876 (spindle microtubule)
GO:0005929 (cilium)
GO:0015630 (microtubule cytoskeleton)
GO:0030496 (midbody)
GO:0031616 (spindle pole centrosome)
GO:0032133 (chromosome passenger complex)
GO:0042585 (germinal vesicle)
GO:0042995 (cell projection)
GO:0043203 (axon hillock)
GO:0045120 (pronucleus)
GO:0048471 (perinuclear region of cytoplasm)
GO:0051233 (spindle midzone)
GO:0072686 (mitotic spindle)
GO:0072687 (meiotic spindle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0035174 (histone serine kinase activity)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000212 (meiotic spindle organization)
GO:0000226 (microtubule cytoskeleton organization)
GO:0000278 (mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007049 (cell cycle)
GO:0007051 (spindle organization)
GO:0007052 (mitotic spindle organization)
GO:0007057 (spindle assembly involved in female meiosis I)
GO:0007067 (mitotic nuclear division)
GO:0007100 (mitotic centrosome separation)
GO:0007126 (meiotic nuclear division)
GO:0009948 (anterior/posterior axis specification)
GO:0016310 (phosphorylation)
GO:0030030 (cell projection organization)
GO:0031145 (anaphase-promoting complex-dependent catabolic process)
GO:0031647 (regulation of protein stability)
GO:0032091 (negative regulation of protein binding)
GO:0032355 (response to estradiol)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032465 (regulation of cytokinesis)
GO:0035404 (histone-serine phosphorylation)
GO:0042787 (protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0046605 (regulation of centrosome cycle)
GO:0046777 (protein autophosphorylation)
GO:0051297 (centrosome organization)
GO:0051301 (cell division)
GO:0051321 (meiotic cell cycle)
GO:0051642 (centrosome localization)
GO:0071539 (protein localization to centrosome)
GO:1900195 (positive regulation of oocyte maturation)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1990138 (neuron projection extension)
Wikipedia Aurora_A_kinase

Target Cross References - Protein

canSAR O14965
Human Protein Atlas ENSG00000087586
IntAct O14965
Guide to Pharmacology 1936
Open Targets ENSG00000087586
PharmGKB PA36201
Pharos O14965 (Tchem)
Reactome R-HSA-174178 (APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-4615885 (SUMOylation of DNA replication proteins.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-8854050 (FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.)
R-HSA-8854518 (AURKA Activation by TPX2.)
R-HSA-8854521 (Interaction between PHLDA1 and AURKA.)
UniProt E1P5F9 O14965 O60445 O75873 Q9BQD6 Q9UPG5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR030611 (AURKA.)
IPR030616 (Aur.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE More...
CREDO 1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE More...
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