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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4718
Target Type SINGLE PROTEIN
Preferred Name MAP kinase-interacting serine/threonine-protein kinase MNK1
Synonyms MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 | MAPK signal-integrating kinase 1 | MKNK1 | MNK1 | Mnk1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase mapkapk family > camk protein kinase mnk subfamily

Target Components

Component Description Relationship Accession
MAP kinase-interacting serine/threonine-protein kinase 1 SINGLE PROTEIN Q9BUB5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000079277
Ensembl ENSG00000079277
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0009931 (calcium-dependent protein serine/threonine kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006417 (regulation of translation)
GO:0006446 (regulation of translational initiation)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0046777 (protein autophosphorylation)
Wikipedia MKNK1

Target Cross References - Protein

canSAR Q9BUB5
Human Protein Atlas ENSG00000079277
IntAct Q9BUB5
Guide to Pharmacology 2104
Open Targets ENSG00000079277
PharmGKB PA30829
Pharos Q9BUB5 (Tchem)
Reactome R-HSA-1295596 (Spry regulation of FGF signaling.)
UniProt D3DQ20 D3DQ21 O00312 Q5TC06 Q5TC07 Q6V0N6 Q9BUB5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2HW6 2Y9Q
CREDO 2HW6 2Y9Q
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