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Target Report Card

Target Name and Classification

Target ID CHEMBL4708
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase MST2
Synonyms KRS1 | MST-2 | MST2 | MST2/C | MST2/N | Mammalian STE20-like protein kinase 2 | STE20-like kinase MST2 | STK3 | Serine/threonine-protein kinase 3 20kDa subunit | Serine/threonine-protein kinase 3 36kDa subunit | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase Krs-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase mst subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase 3 SINGLE PROTEIN Q13188

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104375
Ensembl ENSG00000104375
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0043234 (protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043539 (protein serine/threonine kinase activator activity)
GO:0046872 (metal ion binding)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0001841 (neural tube formation)
GO:0003157 (endocardium development)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007417 (central nervous system development)
GO:0008285 (negative regulation of cell proliferation)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0032092 (positive regulation of protein binding)
GO:0035329 (hippo signaling)
GO:0035556 (intracellular signal transduction)
GO:0043065 (positive regulation of apoptotic process)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0046330 (positive regulation of JNK cascade)
GO:0046621 (negative regulation of organ growth)
GO:0050821 (protein stabilization)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0060215 (primitive hemopoiesis)
GO:0060706 (cell differentiation involved in embryonic placenta development)
GO:0060800 (regulation of cell differentiation involved in embryonic placenta development)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0097284 (hepatocyte apoptotic process)
GO:1902043 (positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)
Wikipedia STK3

Target Cross References - Protein

canSAR Q13188
Human Protein Atlas ENSG00000104375
IntAct Q13188
Guide to Pharmacology 2219
Open Targets ENSG00000104375
PharmGKB PA36213
Pharos Q13188 (Tchem)
Reactome R-HSA-2028269 (Signaling by Hippo.)
UniProt A8K722 B3KYA7 Q13188 Q15445 Q15801 Q96FM6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR011524 (SARAH_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR024205 (Mst1_SARAH_domain.)
Pfam PF00069 (Pkinase)
PF11629 (Mst1_SARAH)

Target Cross References - Structure

PDBe 3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3
CREDO 3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3
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