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Target Report Card

Target Name and Classification

Target ID CHEMBL4703
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Synonyms PP2A-alpha | PPP2CA | RP-C | Replication protein C | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > serine/threonine protein phosphatase

Target Components

Component Description Relationship Accession
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform SINGLE PROTEIN P67775

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113575
Ensembl ENSG00000113575
GO Cellular Component GO:0000159 (protein phosphatase type 2A complex)
GO:0000775 (chromosome, centromeric region)
GO:0000922 (spindle pole)
GO:0005625 (soluble fraction)
GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000188 (inactivation of MAPK activity)
GO:0006275 (regulation of DNA replication)
GO:0006355 (regulation of transcription, DNA-dependent)
GO:0006470 (protein dephosphorylation)
GO:0006672 (ceramide metabolic process)
GO:0006917 (induction of apoptosis)
GO:0007126 (meiosis)
GO:0008380 (RNA splicing)
GO:0010033 (response to organic substance)
GO:0010719 (negative regulation of epithelial to mesenchymal transition)
GO:0019932 (second-messenger-mediated signaling)
GO:0030111 (regulation of Wnt receptor signaling pathway)
GO:0030155 (regulation of cell adhesion)
GO:0030308 (negative regulation of cell growth)
GO:0042518 (negative regulation of tyrosine phosphorylation of Stat3 protein)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
Wikipedia PPP2CA

Target Cross References - Protein

canSAR P67775
Human Protein Atlas ENSG00000113575
IntAct P67775
PharmGKB PA33663
Reactome REACT_11045 (Signaling by Wnt.)
REACT_11061 (Signalling by NGF.)
REACT_1505 (Integration of energy metabolism.)
REACT_152 (Cell Cycle, Mitotic.)
REACT_15295 (Opioid Signalling.)
REACT_383 (DNA Replication.)
REACT_474 (Metabolism of carbohydrates.)
REACT_604 (Hemostasis.)
REACT_6900 (Signaling in Immune system.)
UniProt P05323 P13197 P67775

Target Cross References - Domain

InterPro IPR004843 (Metallo-dependent_phosphatase.)
IPR006186 (Ser/Thr-sp_prot-phosphatase.)
Pfam PF00149 (Metallophos)

Target Cross References - Structure

PDBe 2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71
CREDO 2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71
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