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Target Report Card

Target Name and Classification

Target ID CHEMBL4703
Preferred Name Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Synonyms PP2A-alpha | PPP2CA | RP-C | Replication protein C | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > serine/threonine protein phosphatase

Target Components

Component Description Relationship Accession
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform SINGLE PROTEIN P67775

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113575
Ensembl ENSG00000113575
GO Cellular Component GO:0000159 (protein phosphatase type 2A complex)
GO:0000775 (chromosome, centromeric region)
GO:0000922 (spindle pole)
GO:0005634 (nucleus)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004722 (protein serine/threonine phosphatase activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0050811 (GABA receptor binding)
GO Biological Process GO:0000184 (nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)
GO:0000188 (inactivation of MAPK activity)
GO:0001932 (regulation of protein phosphorylation)
GO:0006275 (regulation of DNA replication)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006470 (protein dephosphorylation)
GO:0006672 (ceramide metabolic process)
GO:0006915 (apoptotic process)
GO:0007084 (mitotic nuclear envelope reassembly)
GO:0007498 (mesoderm development)
GO:0008380 (RNA splicing)
GO:0010033 (response to organic substance)
GO:0010288 (response to lead ion)
GO:0010719 (negative regulation of epithelial to mesenchymal transition)
GO:0019932 (second-messenger-mediated signaling)
GO:0030111 (regulation of Wnt signaling pathway)
GO:0030155 (regulation of cell adhesion)
GO:0030308 (negative regulation of cell growth)
GO:0035970 (peptidyl-threonine dephosphorylation)
GO:0040008 (regulation of growth)
GO:0042532 (negative regulation of tyrosine phosphorylation of STAT protein)
GO:0045595 (regulation of cell differentiation)
GO:0051321 (meiotic cell cycle)
GO:0070262 (peptidyl-serine dephosphorylation)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:1904526 (regulation of microtubule binding)
GO:1904528 (positive regulation of microtubule binding)
Wikipedia PPP2CA

Target Cross References - Protein

canSAR P67775
Human Protein Atlas ENSG00000113575
IntAct P67775
Open Targets ENSG00000113575
PharmGKB PA33663
Reactome R-HSA-113501 (Inhibition of replication initiation of damaged DNA by RB1/E2F1.)
R-HSA-1295596 (Spry regulation of FGF signaling.)
R-HSA-141444 (Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.)
R-HSA-163685 (Integration of energy metabolism.)
R-HSA-163767 (PP2A-mediated dephosphorylation of key metabolic factors.)
R-HSA-180024 (DARPP-32 events.)
R-HSA-195253 (Degradation of beta-catenin by the destruction complex.)
R-HSA-196299 (Beta-catenin phosphorylation cascade.)
R-HSA-198753 (ERK/MAPK targets.)
R-HSA-202670 (ERKs are inactivated.)
R-HSA-2465910 (MASTL Facilitates Mitotic Progression.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-2995383 (Initiation of Nuclear Envelope Reformation.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-432142 (Platelet sensitization by LDL.)
R-HSA-4641262 (Disassembly of the destruction complex and recruitment of AXIN to the membrane.)
R-HSA-5339716 (Misspliced GSK3beta mutants stabilize beta-catenin.)
R-HSA-5358747 (S33 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358749 (S37 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358751 (S45 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358752 (T41 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5467337 (APC truncation mutants have impaired AXIN binding.)
R-HSA-5467340 (AXIN missense mutants destabilize the destruction complex.)
R-HSA-5467348 (Truncations of AMER1 destabilize the destruction complex.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-5673000 (RAF activation.)
R-HSA-5675221 (Negative regulation of MAPK pathway.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-68877 (Mitotic Prometaphase.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-69273 (Cyclin A/B1/B2 associated events during G2/M transition.)
R-HSA-70171 (Glycolysis.)
R-HSA-975957 (Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).)
UniProt P05323 P13197 P67775

Target Cross References - Domain

InterPro IPR004843 (Calcineurin-like_PHP_ApaH.)
IPR006186 (Ser/Thr-sp_prot-phosphatase.)
IPR029052 (Metallo-depent_PP-like.)
Pfam PF00149 (Metallophos)

Target Cross References - Structure

PDBe 2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 5W0W
CREDO 2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 5W0W