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Target Report Card

Target Name and Classification

Target ID CHEMBL4692
Target Type SINGLE PROTEIN
Preferred Name HLA-DR antigens-associated invariant chain
Synonyms CD74 | CD_antigen=CD74 | DHLAG | HLA class II histocompatibility antigen gamma chain | HLA-DR antigens-associated invariant chain | Ia antigen-associated invariant chain | Ii | p33
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other membrane protein

Target Components

Component Description Relationship Accession
HLA class II histocompatibility antigen gamma chain SINGLE PROTEIN P04233

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111430 MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) PROTEIN-PROTEIN INTERACTION

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743040 MILATUZUMAB HLA-DR antigens-associated invariant chain antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000019582
Ensembl ENSG00000019582
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005622 (intracellular)
GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005770 (late endosome)
GO:0005771 (multivesicular body)
GO:0005773 (vacuole)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0012507 (ER to Golgi transport vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030658 (transport vesicle membrane)
GO:0030666 (endocytic vesicle membrane)
GO:0030669 (clathrin-coated endocytic vesicle membrane)
GO:0032588 (trans-Golgi network membrane)
GO:0035692 (macrophage migration inhibitory factor receptor complex)
GO:0035693 (NOS2-CD74 complex)
GO:0042613 (MHC class II protein complex)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO:0071556 (integral component of lumenal side of endoplasmic reticulum membrane)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004896 (cytokine receptor activity)
GO:0005515 (protein binding)
GO:0019955 (cytokine binding)
GO:0023026 (MHC class II protein complex binding)
GO:0035718 (macrophage migration inhibitory factor binding)
GO:0042289 (MHC class II protein binding)
GO:0042658 (MHC class II protein binding, via antigen binding groove)
GO:0042802 (identical protein binding)
GO:0044183 (protein binding involved in protein folding)
GO:0050998 (nitric-oxide synthase binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001516 (prostaglandin biosynthetic process)
GO:0001961 (positive regulation of cytokine-mediated signaling pathway)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002606 (positive regulation of dendritic cell antigen processing and presentation)
GO:0002792 (negative regulation of peptide secretion)
GO:0002830 (positive regulation of type 2 immune response)
GO:0002906 (negative regulation of mature B cell apoptotic process)
GO:0006461 (protein complex assembly)
GO:0006886 (intracellular protein transport)
GO:0006952 (defense response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0008283 (cell proliferation)
GO:0016064 (immunoglobulin mediated immune response)
GO:0019882 (antigen processing and presentation)
GO:0019883 (antigen processing and presentation of endogenous antigen)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0030890 (positive regulation of B cell proliferation)
GO:0035691 (macrophage migration inhibitory factor signaling pathway)
GO:0043030 (regulation of macrophage activation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator)
GO:0045058 (T cell selection)
GO:0045059 (positive thymic T cell selection)
GO:0045060 (negative thymic T cell selection)
GO:0045581 (negative regulation of T cell differentiation)
GO:0045582 (positive regulation of T cell differentiation)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050900 (leukocyte migration)
GO:0051085 (chaperone mediated protein folding requiring cofactor)
GO:0060907 (positive regulation of macrophage cytokine production)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090023 (positive regulation of neutrophil chemotaxis)
GO:1902166 (negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:2000343 (positive regulation of chemokine (C-X-C motif) ligand 2 production)
Wikipedia CD74

Target Cross References - Protein

canSAR P04233
Human Protein Atlas ENSG00000019582
IntAct P04233
Guide to Pharmacology 2840
Open Targets ENSG00000019582
PharmGKB PA26236
Reactome R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-2132295 (MHC class II antigen presentation.)
TIMBAL CD74
UniProt A8K7R1 B4DNE8 D3DQG3 D3DQG4 P04233 Q14597 Q29832 Q5U0J8 Q8SNA0 Q8WLP6

Target Cross References - Domain

InterPro IPR000716 (Thyroglobulin_1.)
IPR011988 (MHC_II-assoc_invariant_trimer.)
IPR015386 (MHC_II-assoc_invar/CLIP_MHC-bd.)
IPR022339 (MHC_II-assoc_invar_chain.)
Pfam PF00086 (Thyroglobulin_1)
PF08831 (MHCassoc_trimer)
PF09307 (MHC2-interact)

Target Cross References - Structure

PDBe 1A6A 1ICF 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W
CREDO 1A6A 1ICF 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W
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