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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4685
Target Type SINGLE PROTEIN
Preferred Name Indoleamine 2,3-dioxygenase
Synonyms IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-dioxygenase 1 | Indoleamine-pyrrole 2,3-dioxygenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Indoleamine 2,3-dioxygenase 1 SINGLE PROTEIN P14902

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131203
Ensembl ENSG00000131203
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004833 (tryptophan 2,3-dioxygenase activity)
GO:0009055 (electron carrier activity)
GO:0020037 (heme binding)
GO:0033754 (indoleamine 2,3-dioxygenase activity)
GO Biological Process GO:0006569 (tryptophan catabolic process)
GO:0007565 (female pregnancy)
Wikipedia Indoleamine_2,3-dioxygenase

Target Cross References - Protein

canSAR P14902
Human Protein Atlas ENSG00000131203
IntAct P14902
PharmGKB PA29869
Reactome REACT_13 (Metabolism of amino acids and derivatives.)
UniProt P14902 Q540B4

Target Cross References - Domain

InterPro IPR000898 (Indolamine_dOase.)
Pfam PF01231 (IDO)

Target Cross References - Structure

PDBe 2D0T 2D0U
CREDO 2D0T 2D0U
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