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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4685
Target Type SINGLE PROTEIN
Preferred Name Indoleamine 2,3-dioxygenase
Synonyms IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-dioxygenase 1 | Indoleamine-pyrrole 2,3-dioxygenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Indoleamine 2,3-dioxygenase 1 SINGLE PROTEIN P14902

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545369 EPACADOSTAT Indoleamine 2,3-dioxygenase inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131203
Ensembl ENSG00000131203
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0030485 (smooth muscle contractile fiber)
GO:0032421 (stereocilium bundle)
GO Molecular Function GO:0004833 (tryptophan 2,3-dioxygenase activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0033754 (indoleamine 2,3-dioxygenase activity)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0002376 (immune system process)
GO:0002534 (cytokine production involved in inflammatory response)
GO:0002666 (positive regulation of T cell tolerance induction)
GO:0002678 (positive regulation of chronic inflammatory response)
GO:0002830 (positive regulation of type 2 immune response)
GO:0006569 (tryptophan catabolic process)
GO:0006954 (inflammatory response)
GO:0007565 (female pregnancy)
GO:0019441 (tryptophan catabolic process to kynurenine)
GO:0032496 (response to lipopolysaccharide)
GO:0032693 (negative regulation of interleukin-10 production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0033555 (multicellular organismal response to stress)
GO:0034276 (kynurenic acid biosynthetic process)
GO:0036269 (swimming behavior)
GO:0042130 (negative regulation of T cell proliferation)
GO:0043065 (positive regulation of apoptotic process)
GO:0046006 (regulation of activated T cell proliferation)
GO:0055114 (oxidation-reduction process)
GO:0070233 (negative regulation of T cell apoptotic process)
GO:0070234 (positive regulation of T cell apoptotic process)
Wikipedia Indoleamine_2,3-dioxygenase

Target Cross References - Protein

canSAR P14902
Human Protein Atlas ENSG00000131203
IntAct P14902
Guide to Pharmacology 2829
Open Targets ENSG00000131203
PharmGKB PA29869
Reactome R-HSA-71240 (Tryptophan catabolism.)
UniProt E5RGR8 F6M9T7 P14902 Q540B4

Target Cross References - Domain

InterPro IPR000898 (Indolamine_dOase.)
Pfam PF01231 (IDO)

Target Cross References - Structure

PDBe 2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW
CREDO 2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW
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