ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4683
Preferred Name Fibroblast activation protein alpha
Synonyms 170 kDa melanoma membrane-bound gelatinase | APCE | Antiplasmin-cleaving enzyme FAP, soluble form | Dipeptidyl peptidase FAP | FAP | FAPalpha | Fibroblast activation protein alpha | Gelatine degradation protease FAP | Integral membrane serine protease | Post-proline cleaving enzyme | Prolyl endopeptidase FAP | SIMP | Seprase | Serine integral membrane protease | Surface-expressed protease
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s9b subfamily

Target Components

Component Description Relationship Accession
Prolyl endopeptidase FAP SINGLE PROTEIN Q12884

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000078098
Ensembl ENSG00000078098
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0031258 (lamellipodium membrane)
GO:0032587 (ruffle membrane)
GO:0042995 (cell projection)
GO:0045177 (apical part of cell)
GO:0045178 (basal part of cell)
GO:0071438 (invadopodium membrane)
GO Molecular Function GO:0002020 (protease binding)
GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0008239 (dipeptidyl-peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042803 (protein homodimerization activity)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006508 (proteolysis)
GO:0006915 (apoptotic process)
GO:0007155 (cell adhesion)
GO:0010710 (regulation of collagen catabolic process)
GO:0010716 (negative regulation of extracellular matrix disassembly)
GO:0043542 (endothelial cell migration)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0051917 (regulation of fibrinolysis)
GO:0060244 (negative regulation of cell proliferation involved in contact inhibition)
GO:0071158 (positive regulation of cell cycle arrest)
GO:0071850 (mitotic cell cycle arrest)
GO:0097325 (melanocyte proliferation)
GO:1900119 (positive regulation of execution phase of apoptosis)
GO:1902362 (melanocyte apoptotic process)
GO:1903054 (negative regulation of extracellular matrix organization)
Wikipedia Fibroblast_activation_protein,_alpha

Target Cross References - Protein

canSAR Q12884
Human Protein Atlas ENSG00000078098
IntAct Q12884
Guide to Pharmacology 2365
Open Targets ENSG00000078098
PharmGKB PA28003
UniProt O00199 Q12884 Q53TP5 Q86Z29 Q99998 Q9UID4

Target Cross References - Domain

InterPro IPR001375 (Peptidase_S9.)
IPR002469 (Peptidase_S9B_N.)
IPR002471 (Pept_S9_AS.)
IPR029058 (AB_hydrolase.)
IPR031245 (FAP/Dpf2.)
Pfam PF00326 (Peptidase_S9)
PF00930 (DPPIV_N)

Target Cross References - Structure

PDBe 1Z68