ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4666
Preferred Name Steroidogenic factor 1
Synonyms AD4BP | Adrenal 4-binding protein | FTZF1 | Fushi tarazu factor homolog 1 | NR5A1 | Nuclear receptor subfamily 5 group A member 1 | SF-1 | SF1 | STF-1 | Steroid hormone receptor Ad4BP | Steroidogenic factor 1 | hSF-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 5 > nuclear hormone receptor subfamily 5 group a > nuclear hormone receptor subfamily 5 group a member 1

Target Components

Component Description Relationship Accession
Steroidogenic factor 1 SINGLE PROTEIN Q13285

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136931
Ensembl ENSG00000136931
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000976 (transcription regulatory region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0019899 (enzyme binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001553 (luteinization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007267 (cell-cell signaling)
GO:0007538 (primary sex determination)
GO:0008584 (male gonad development)
GO:0008585 (female gonad development)
GO:0009755 (hormone-mediated signaling pathway)
GO:0009888 (tissue development)
GO:0010259 (multicellular organism aging)
GO:0022414 (reproductive process)
GO:0030154 (cell differentiation)
GO:0030325 (adrenal gland development)
GO:0030522 (intracellular receptor signaling pathway)
GO:0042445 (hormone metabolic process)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050810 (regulation of steroid biosynthetic process)
GO:0051457 (maintenance of protein location in nucleus)
GO:2000020 (positive regulation of male gonad development)
GO:2000195 (negative regulation of female gonad development)
Wikipedia Steroidogenic_factor_1

Target Cross References - Protein

canSAR Q13285
CGD Adrenocortical insufficiency; 46, XY sex reversal, 3; Premature ovarian failure 7
Human Protein Atlas ENSG00000136931
IntAct Q13285
Open Targets ENSG00000136931
PharmGKB PA31764
Pharos Q13285 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-452723 (Transcriptional regulation of pluripotent stem cells.)
UniProt O15196 Q13285 Q5T6F5

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR016355 (NR5_fam.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure