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Target Report Card

Target Name and Classification

Target ID CHEMBL4662
Target Type SINGLE PROTEIN
Preferred Name Proteasome Macropain subunit MB1
Synonyms LMPX | MB1 | Macropain epsilon chain | Multicatalytic endopeptidase complex epsilon chain | PSMB5 | Proteasome chain 6 | Proteasome epsilon chain | Proteasome subunit MB1 | Proteasome subunit X | Proteasome subunit beta type-5 | X
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > threonine protease > threonine protease pbt clan > threonine protease t1a subfamily

Target Components

Component Description Relationship Accession
Proteasome subunit beta type-5 SINGLE PROTEIN P28074

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2364701 26S proteosome PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100804
Ensembl ENSG00000100804
GO Cellular Component GO:0000502 (proteasome complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005839 (proteasome core complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004298 (threonine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000209 (protein polyubiquitination)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002479 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)
GO:0006508 (proteolysis)
GO:0006521 (regulation of cellular amino acid metabolic process)
GO:0006979 (response to oxidative stress)
GO:0016032 (viral process)
GO:0031145 (anaphase-promoting complex-dependent catabolic process)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0043488 (regulation of mRNA stability)
GO:0050852 (T cell receptor signaling pathway)
GO:0051436 (negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)
GO:0051437 (positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
Wikipedia PSMB5

Target Cross References - Protein

canSAR P28074
Human Protein Atlas ENSG00000100804
IntAct P28074
Guide to Pharmacology 2406
Open Targets ENSG00000100804
PharmGKB PA33887
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-1236974 (ER-Phagosome pathway.)
R-HSA-1236978 (Cross-presentation of soluble exogenous antigens (endosomes).)
R-HSA-174084 (Autodegradation of Cdh1 by Cdh1:APC/C.)
R-HSA-174113 (SCF-beta-TrCP mediated degradation of Emi1.)
R-HSA-174154 (APC/C:Cdc20 mediated degradation of Securin.)
R-HSA-174178 (APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.)
R-HSA-174184 (Cdc20:Phospho-APC/C mediated degradation of Cyclin A.)
R-HSA-180534 (Vpu mediated degradation of CD4.)
R-HSA-180585 (Vif-mediated degradation of APOBEC3G.)
R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-195253 (Degradation of beta-catenin by the destruction complex.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-211733 (Regulation of activated PAK-2p34 by proteasome mediated degradation.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-349425 (Autodegradation of the E3 ubiquitin ligase COP1.)
R-HSA-350562 (Regulation of ornithine decarboxylase (ODC).)
R-HSA-450408 (AUF1 (hnRNP D0) binds and destabilizes mRNA.)
R-HSA-4608870 (Asymmetric localization of PCP proteins.)
R-HSA-4641257 (Degradation of AXIN.)
R-HSA-4641258 (Degradation of DVL.)
R-HSA-5358346 (Hedgehog ligand biogenesis.)
R-HSA-5362768 (Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.)
R-HSA-5607761 (Dectin-1 mediated noncanonical NF-kB signaling.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5610780 (Degradation of GLI1 by the proteasome.)
R-HSA-5610783 (Degradation of GLI2 by the proteasome.)
R-HSA-5610785 (GLI3 is processed to GLI3R by the proteasome.)
R-HSA-5632684 (Hedgehog 'on' state.)
R-HSA-5658442 (Regulation of RAS by GAPs.)
R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-5676590 (NIK-->noncanonical NF-kB signaling.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-68827 (CDT1 association with the CDC6:ORC:origin complex.)
R-HSA-68949 (Orc1 removal from chromatin.)
R-HSA-69017 (CDK-mediated phosphorylation and removal of Cdc6.)
R-HSA-69229 (Ubiquitin-dependent degradation of Cyclin D1.)
R-HSA-69481 (G2/M Checkpoints.)
R-HSA-69601 (Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.)
R-HSA-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
R-HSA-983168 (Antigen processing: Ubiquitination & Proteasome degradation.)
UniProt B2R4N9 B4DUM9 D3DS43 E9PAV2 P28074 Q16242 Q6PEW2 Q7Z3B5 Q86T01 Q9TNN9

Target Cross References - Domain

InterPro IPR000243 (Pept_T1A_subB.)
IPR001353 (Proteasome_sua/b.)
IPR016050 (Proteasome_bsu_CS.)
IPR023333 (Proteasome_suB-type.)
IPR029055 (Ntn_hydrolases_N.)
Pfam PF00227 (Proteasome)

Target Cross References - Structure

PDBe 4R3O 4R67
CREDO 4R3O 4R67
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