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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4644
Target Type SINGLE PROTEIN
Preferred Name Melanocortin receptor 3
Synonyms MC3-R | MC3R | Melanocortin receptor 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > melanocortin receptor

Target Components

Component Description Relationship Accession
Melanocortin receptor 3 SINGLE PROTEIN P41968

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111323 Melanocortin receptor (M3 and M4) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2070241 BREMELANOTIDE Melanocortin receptor 3 agonist 3 PubMed PubMed
CHEMBL3545104 Modimelanotide Melanocortin receptor 3 agonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124089
Ensembl ENSG00000124089
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004977 (melanocortin receptor activity)
GO:0004980 (melanocyte-stimulating hormone receptor activity)
GO:0005515 (protein binding)
GO:0017046 (peptide hormone binding)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0002027 (regulation of heart rate)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0008217 (regulation of blood pressure)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0032922 (circadian regulation of gene expression)
GO:0042309 (homoiothermy)
GO:0045475 (locomotor rhythm)
GO:0048511 (rhythmic process)
GO:0055078 (sodium ion homeostasis)
GO:0060259 (regulation of feeding behavior)
Wikipedia Melanocortin_3_receptor

Target Cross References - Protein

canSAR P41968
Human Protein Atlas ENSG00000124089
IntAct P41968
Guide to Pharmacology 284
Open Targets ENSG00000124089
PharmGKB PA30675
Pharos P41968 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt P41968 Q4KN27 Q9H517

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001671 (Melcrt_ACTH_rcpt.)
IPR001908 (Melancort_rcpt.)
IPR002122 (Mcort_3_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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