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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4644
Preferred Name Melanocortin receptor 3
Synonyms MC3-R | MC3R | Melanocortin receptor 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > melanocortin receptor

Target Components

Component Description Relationship Accession
Melanocortin receptor 3 SINGLE PROTEIN P41968

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111323 Melanocortin receptor (M3 and M4) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124089
Ensembl ENSG00000124089
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004980 (melanocyte-stimulating hormone receptor activity)
GO:0005515 (protein binding)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0007200 (activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger)
GO:0030819 (positive regulation of cAMP biosynthetic process)
Wikipedia Melanocortin_3_receptor

Target Cross References - Protein

canSAR P41968
Human Protein Atlas ENSG00000124089
Guide to Pharmacology 284 (MC3)
PharmGKB PA30675
Reactome REACT_14797 (Signaling by GPCR.)
UniProt P41968 Q4KN27 Q9H517

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR001671 (Melcrt_ACTH_rcpt.)
IPR001908 (Melancort_rcpt.)
IPR002122 (Mcort_3_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)