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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4629
Target Type SINGLE PROTEIN
Preferred Name Complement factor H
Synonyms CFH | Complement factor H | H factor 1 | HF | HF1 | HF2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Complement factor H SINGLE PROTEIN P08603

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000000971
Ensembl ENSG00000000971
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0043395 (heparan sulfate proteoglycan binding)
GO Biological Process GO:0002376 (immune system process)
GO:0006956 (complement activation)
GO:0006957 (complement activation, alternative pathway)
GO:0030449 (regulation of complement activation)
GO:0045087 (innate immune response)
Wikipedia Factor_H

Target Cross References - Protein

canSAR P08603
CGD Hemolytic uremic syndrome, atypical; Complement factor H deficiency
Human Protein Atlas ENSG00000000971
IntAct P08603
Open Targets ENSG00000000971
PharmGKB PA29261
Reactome R-HSA-977606 (Regulation of Complement cascade.)
UniProt A5PL14 P08603 P78435 Q14570 Q2TAZ5 Q38G77 Q5TFM3 Q8N708 Q9NU86

Target Cross References - Domain

InterPro IPR000436 (Sushi_SCR_CCP_dom.)
Pfam PF00084 (Sushi)

Target Cross References - Structure

PDBe 2G7I 2UWN 2V8E 2W80 2W81 2WII 2XQW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4J38 4K12 4ONT 4ZH1
CREDO 2G7I 2UWN 2V8E 2W80 2W81 2WII 2XQW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4J38 4K12 4ONT 4ZH1
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