ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4627
Preferred Name Myosin light chain kinase
Synonyms Cardiac-MLCK | Cardiac-MyBP-C-associated Ca/CaM kinase | MLCK | MYLK3 | Myosin light chain kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase mlck family

Target Components

Component Description Relationship Accession
Myosin light chain kinase 3 SINGLE PROTEIN Q32MK0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140795
Ensembl ENSG00000140795
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0015629 (actin cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0004687 (myosin light chain kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0002528 (regulation of vascular permeability involved in acute inflammatory response)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0045214 (sarcomere organization)
GO:0048769 (sarcomerogenesis)
GO:0055003 (cardiac myofibril assembly)
GO:0060298 (positive regulation of sarcomere organization)
GO:0071347 (cellular response to interleukin-1)
Wikipedia MYLK3

Target Cross References - Protein

canSAR Q32MK0
Human Protein Atlas ENSG00000140795
IntAct Q32MK0
Guide to Pharmacology 2110
Open Targets ENSG00000140795
PharmGKB PA162396375
Pharos Q32MK0 (Tchem)
UniProt B5BUL9 B7Z5U8 Q32MK0 Q32MK1 Q96DV1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)