ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4625
Target Type SINGLE PROTEIN
Preferred Name Apoptosis regulator Bcl-X
Synonyms Apoptosis regulator Bcl-X | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 | Bcl2-L-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > bcl-2 family

Target Components

Component Description Relationship Accession
Bcl-2-like protein 1 SINGLE PROTEIN Q07817

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137283 Bcl-xL/BAK PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171552
Ensembl ENSG00000171552
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005743 (mitochondrial inner membrane)
GO:0005759 (mitochondrial matrix)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0016021 (integral component of membrane)
GO:0016021 (integral to membrane)
GO:0030054 (cell junction)
GO:0030672 (synaptic vesicle membrane)
GO:0031965 (nuclear membrane)
GO:0097136 (Bcl-2 family protein complex)
GO Molecular Function GO:0019901 (protein kinase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051434 (BH3 domain binding)
GO Biological Process GO:0000910 (cytokinesis)
GO:0001541 (ovarian follicle development)
GO:0001701 (in utero embryonic development)
GO:0001836 (release of cytochrome c from mitochondria)
GO:0006897 (endocytosis)
GO:0006915 (apoptotic process)
GO:0007093 (mitotic cell cycle checkpoint)
GO:0007281 (germ cell development)
GO:0007283 (spermatogenesis)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008584 (male gonad development)
GO:0008629 (induction of apoptosis by intracellular signals)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0008634 (negative regulation of survival gene product expression)
GO:0008637 (apoptotic mitochondrial changes)
GO:0009566 (fertilization)
GO:0010507 (negative regulation of autophagy)
GO:0012501 (programmed cell death)
GO:0019050 (suppression by virus of host apoptotic process)
GO:0034097 (response to cytokine)
GO:0034097 (response to cytokine stimulus)
GO:0035872 (nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway)
GO:0040007 (growth)
GO:0043066 (negative regulation of apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045087 (innate immune response)
GO:0046898 (response to cycloheximide)
GO:0046902 (regulation of mitochondrial membrane permeability)
GO:0051402 (neuron apoptotic process)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0060154 (cellular process regulating host cell cycle in response to virus)
GO:0070584 (mitochondrion morphogenesis)
GO:0071230 (cellular response to amino acid stimulus)
GO:0071312 (cellular response to alkaloid)
GO:0071480 (cellular response to gamma radiation)
GO:0071839 (apoptotic process in bone marrow)
GO:0090005 (negative regulation of establishment of protein localization in plasma membrane)
GO:0090005 (negative regulation of establishment of protein localization to plasma membrane)
GO:0090201 (negative regulation of release of cytochrome c from mitochondria)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:0097284 (hepatocyte apoptotic process)
GO:1900118 (negative regulation of execution phase of apoptosis)
GO:1902230 (negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)
GO:2000811 (negative regulation of anoikis)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway)
Wikipedia BCL2-like_1_(gene)

Target Cross References - Protein

canSAR Q07817
Human Protein Atlas ENSG00000171552
IntAct Q07817
PharmGKB PA76
TIMBAL Bcl-XL%20and%20Bcl-2
UniProt E1P5L6 Q07817 Q5CZ89 Q5TE65 Q92976

Target Cross References - Domain

InterPro IPR000712 (Bcl2_BH.)
IPR002475 (Bcl2-like.)
IPR002475 (Bcl2-like_apoptosis.)
IPR003093 (Bcl2_BH4.)
IPR004725 (Bcl2/BclX.)
IPR004725 (Bcl2_reg.)
IPR013279 (Apop_reg_BclX.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020728 (Bcl2_BH3_motif_CS.)
IPR020731 (Bcl2_BH4_motif_CS.)
IPR026298 (Blc2_fam.)
Pfam PF00452 (Bcl-2)
PF02180 (BH4)

Target Cross References - Structure

PDBe 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 2B48 2P1L 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3WIZ 3ZK6 More...
CREDO 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 2B48 2P1L 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3WIZ 3ZK6 More...
spacer
spacer