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Target Report Card

Target Name and Classification

Target ID CHEMBL4616
Preferred Name Ghrelin receptor
Synonyms GH-releasing peptide receptor | GHRP | GHS-R | GHSR | Ghrelin receptor | Growth hormone secretagogue receptor type 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > grp-related receptor

Target Components

Component Description Relationship Accession
Growth hormone secretagogue receptor type 1 SINGLE PROTEIN Q92847

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL278623 MACIMORELIN Ghrelin receptor agonist 3 Other PubMed PubMed
CHEMBL1923502 ULIMORELIN HYDROCHLORIDE Ghrelin receptor agonist 3 PubMed
CHEMBL2103794 ANAMORELIN HYDROCHLORIDE Ghrelin receptor agonist 3 PubMed
CHEMBL281764 TABIMORELIN Ghrelin receptor agonist 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121853
Ensembl ENSG00000121853
GO Cellular Component GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO:0045121 (membrane raft)
GO Molecular Function GO:0001616 (growth hormone secretagogue receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0016520 (growth hormone-releasing hormone receptor activity)
GO:0017046 (peptide hormone binding)
GO:0042562 (hormone binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0008154 (actin polymerization or depolymerization)
GO:0008343 (adult feeding behavior)
GO:0009725 (response to hormone)
GO:0009755 (hormone-mediated signaling pathway)
GO:0030252 (growth hormone secretion)
GO:0032094 (response to food)
GO:0032100 (positive regulation of appetite)
GO:0032691 (negative regulation of interleukin-1 beta production)
GO:0032869 (cellular response to insulin stimulus)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042536 (negative regulation of tumor necrosis factor biosynthetic process)
GO:0043134 (regulation of hindgut contraction)
GO:0043568 (positive regulation of insulin-like growth factor receptor signaling pathway)
GO:0045409 (negative regulation of interleukin-6 biosynthetic process)
GO:0045923 (positive regulation of fatty acid metabolic process)
GO:0046676 (negative regulation of insulin secretion)
GO:0046697 (decidualization)
GO:0050728 (negative regulation of inflammatory response)
GO:0051963 (regulation of synapse assembly)
Wikipedia Growth_hormone_secretagogue_receptor

Target Cross References - Protein

canSAR Q92847
CGD Short stature
Human Protein Atlas ENSG00000121853
Guide to Pharmacology 246
Open Targets ENSG00000121853
PharmGKB PA28677
Pharos Q92847 (Tclin)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt Q14D12 Q6ISR8 Q92847 Q92848 Q96RJ7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR003905 (GHS-R.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)