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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4611
Target Type SINGLE PROTEIN
Preferred Name Complement C1r
Synonyms C1R | Complement C1r subcomponent heavy chain | Complement C1r subcomponent light chain | Complement C1r subcomponent | Complement component 1 subcomponent r
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Complement C1r subcomponent SINGLE PROTEIN P00736

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000159403
Ensembl ENSG00000159403
GO Cellular Component GO:0005576 (extracellular region)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0002376 (immune system process)
GO:0006508 (proteolysis)
GO:0006955 (immune response)
GO:0006956 (complement activation)
GO:0006958 (complement activation, classical pathway)
GO:0045087 (innate immune response)
Wikipedia C1R_(gene)

Target Cross References - Protein

canSAR P00736
Human Protein Atlas ENSG00000159403
IntAct P00736
Guide to Pharmacology 2334
Open Targets ENSG00000159403
PharmGKB PA25635
Reactome R-HSA-166663 (Initial triggering of complement.)
R-HSA-173623 (Classical antibody-mediated complement activation.)
UniProt A6NJQ8 P00736 Q68D77 Q8J012

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000436 (Sushi_SCR_CCP_dom.)
IPR000742 (EGF-like_dom.)
IPR000859 (CUB_dom.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR013032 (EGF-like_CS.)
IPR018097 (EGF_Ca-bd_CS.)
IPR024175 (Pept_S1A_C1r/C1S/mannan-bd.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00084 (Sushi)
PF00089 (Trypsin)
PF00431 (CUB)

Target Cross References - Structure

PDBe 1GPZ 1MD7 1MD8 2QY0
CREDO 1GPZ 1MD7 1MD8 2QY0
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