ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4610
Preferred Name Xaa-Pro aminopeptidase 2
Synonyms Aminoacylproline aminopeptidase | Membrane-bound APP | Membrane-bound AmP | Membrane-bound aminopeptidase P | X-Pro aminopeptidase 2 | XPNPEP2 | Xaa-Pro aminopeptidase 2 | mAmP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mg clan > metallo protease m24b subfamily

Target Components

Component Description Relationship Accession
Xaa-Pro aminopeptidase 2 SINGLE PROTEIN O43895

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122121
Ensembl ENSG00000122121
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031225 (anchored component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0006501 (C-terminal protein lipidation)
GO:0006508 (proteolysis)
Wikipedia XPNPEP2

Target Cross References - Protein

canSAR O43895
CGD Angioedema induced by ACE inhibitors, susceptibility to
Human Protein Atlas ENSG00000122121
Guide to Pharmacology 1579
Open Targets ENSG00000122121
PharmGKB PA37416
Reactome R-HSA-163125 (Post-translational modification: synthesis of GPI-anchored proteins.)
UniProt A0AV16 O43895 O75994

Target Cross References - Domain

InterPro IPR000587 (Creatinase_N.)
IPR000994 (Pept_M24.)
IPR001131 (Peptidase_M24B_aminopep-P_CS.)
IPR029149 (Creatin/AminoP/Spt16_NTD.)
IPR032416 (Peptidase_M24_C.)
IPR033740 (Pept_M24B.)
IPR036005 (Creatinase/aminopeptidase-like.)
Pfam PF00557 (Peptidase_M24)
PF01321 (Creatinase_N)
PF16188 (Peptidase_M24_C)