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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4602
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-A receptor 7
Synonyms EHK-3 | EHK3 | EK11 | EPH homology kinase 3 | EPH-like kinase 11 | EPHA7 | Ephrin type-A receptor 7 | HEK11 | hEK11
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-A receptor 7 SINGLE PROTEIN Q15375

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135333
Ensembl ENSG00000135333
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0031594 (neuromuscular junction)
GO:0043025 (neuronal cell body)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005004 (GPI-linked ephrin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008046 (axon guidance receptor activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0045499 (chemorepellent activity)
GO:0046875 (ephrin receptor binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007420 (brain development)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0022407 (regulation of cell-cell adhesion)
GO:0031290 (retinal ganglion cell axon guidance)
GO:0031952 (regulation of protein autophosphorylation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048671 (negative regulation of collateral sprouting)
GO:0048755 (branching morphogenesis of a nerve)
GO:0050730 (regulation of peptidyl-tyrosine phosphorylation)
GO:0050919 (negative chemotaxis)
GO:0051964 (negative regulation of synapse assembly)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0072178 (nephric duct morphogenesis)
Wikipedia EPHA7

Target Cross References - Protein

canSAR Q15375
Human Protein Atlas ENSG00000135333
IntAct Q15375
Guide to Pharmacology 1827
Open Targets ENSG00000135333
PharmGKB PA27822
Pharos Q15375 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt A0AUX7 B2R8W1 B7ZLJ9 B7ZLK0 Q15375 Q59G40 Q5VTU0 Q8N368 Q9H124

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like.)
IPR009030 (Growth_fac_rcpt_.)
IPR011009 (Kinase-like_dom.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
IPR034283 (EphA7_rcpt_lig-bd.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07699 (Ephrin_rec_like)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure

PDBe 2REI 3DKO 3H8M 3NRU
CREDO 2REI 3DKO 3H8M 3NRU
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