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Target Report Card

Target Name and Classification

Target ID CHEMBL4600
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PAK 1
Synonyms Alpha-PAK | PAK-1 | PAK1 | Serine/threonine-protein kinase PAK 1 | p21-activated kinase 1 | p65-PAK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase paka subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 1 SINGLE PROTEIN Q13153

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149269
Ensembl ENSG00000149269
GO Cellular Component GO:0001726 (ruffle)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005925 (focal adhesion)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0030018 (Z disc)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031941 (filamentous actin)
GO:0031965 (nuclear membrane)
GO:0032587 (ruffle membrane)
GO:0042995 (cell projection)
GO:0043234 (protein complex)
GO:0071437 (invadopodium)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000278 (mitotic cell cycle)
GO:0001666 (response to hypoxia)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006887 (exocytosis)
GO:0006915 (apoptotic process)
GO:0007409 (axonogenesis)
GO:0008152 (metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0010033 (response to organic substance)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030335 (positive regulation of cell migration)
GO:0031295 (T cell costimulation)
GO:0031532 (actin cytoskeleton reorganization)
GO:0032869 (cellular response to insulin stimulus)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033148 (positive regulation of intracellular estrogen receptor signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042060 (wound healing)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0048812 (neuron projection morphogenesis)
GO:0050852 (T cell receptor signaling pathway)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0060244 (negative regulation of cell proliferation involved in contact inhibition)
Wikipedia PAK1

Target Cross References - Protein

canSAR Q13153
Human Protein Atlas ENSG00000149269
IntAct Q13153
Guide to Pharmacology 2133
Open Targets ENSG00000149269
PharmGKB PA32917
Pharos Q13153 (Tchem)
Reactome R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-428540 (Activation of Rac.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
UniProt O75561 Q13153 Q13567 Q32M53 Q32M54 Q86W79

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)

Target Cross References - Structure

PDBe 1F3M 1YHV 1YHW 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEY 5DFP
CREDO 1F3M 1YHV 1YHW 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEY 5DFP
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