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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4600
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PAK 1
Synonyms Alpha-PAK | PAK-1 | PAK1 | Serine/threonine-protein kinase PAK 1 | p21-activated kinase 1 | p65-PAK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase paka subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 1 SINGLE PROTEIN Q13153

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149269
Ensembl ENSG00000149269
GO Cellular Component GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006915 (apoptosis)
GO:0006984 (ER-nucleus signaling pathway)
GO:0007010 (cytoskeleton organization)
GO:0007411 (axon guidance)
GO:0031295 (T cell costimulation)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0046777 (protein autophosphorylation)
GO:0050852 (T cell receptor signaling pathway)
Wikipedia PAK1

Target Cross References - Protein

canSAR Q13153
Human Protein Atlas ENSG00000149269
IntAct Q13153
Guide to Pharmacology 2133 (p21 protein (Cdc42/Rac)-activated kinase 1)
PharmGKB PA32917
Reactome REACT_18266 (Axon guidance.)
REACT_23853 (Interactions of the immunoglobulin superfamily (IgSF) member proteins.)
REACT_6900 (Signaling in Immune system.)
UniProt O75561 Q13153 Q13567 Q32M53 Q32M54 Q86W79

Target Cross References - Domain

InterPro IPR000095 (PAK_box_Rho-bd.)
IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)

Target Cross References - Structure

PDBe 1F3M 1YHV 1YHW 2HY8 2QME 3DVP 3FXZ 3FY0
CREDO 1F3M 1YHV 1YHW 2HY8 2QME 3DVP 3FXZ 3FY0
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